[HTML][HTML] SARS-CoV-2 infection of primary human lung epithelium for COVID-19 modeling and drug discovery
Summary Coronavirus disease 2019 (COVID-19) is the latest respiratory pandemic caused
by severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2). Although …
by severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2). Although …
[HTML][HTML] Human Lung Organoids—A Novel Experimental and Precision Medicine Approach
L Kühl, P Graichen, N von Daacke, A Mende… - Cells, 2023 - mdpi.com
The global burden of respiratory diseases is very high and still on the rise, prompting the
need for accurate models for basic and translational research. Several model systems are …
need for accurate models for basic and translational research. Several model systems are …
[HTML][HTML] A barrier to defend-models of pulmonary barrier to study acute inflammatory diseases
Pulmonary diseases represent four out of ten most common causes for worldwide mortality.
Thus, pulmonary infections with subsequent inflammatory responses represent a major …
Thus, pulmonary infections with subsequent inflammatory responses represent a major …
[HTML][HTML] Alveolar Organoids in Lung Disease Modeling
E Purev, K Bahmed, B Kosmider - Biomolecules, 2024 - mdpi.com
Lung organoids display a tissue-specific functional phenomenon and mimic the features of
the original organ. They can reflect the properties of the cells, such as morphology, polarity …
the original organ. They can reflect the properties of the cells, such as morphology, polarity …
[HTML][HTML] Differential lysotracker uptake defines two populations of distal epithelial cells in idiopathic pulmonary fibrosis
RM Wasnick, I Shalashova, J Wilhelm, A Khadim… - Cells, 2022 - mdpi.com
Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal degenerative lung disease of
unknown etiology. Although in its final stages it implicates, in a reactive manner, all lung cell …
unknown etiology. Although in its final stages it implicates, in a reactive manner, all lung cell …
[HTML][HTML] Influence of mesenchymal and biophysical components on distal lung organoid differentiation
O Goltsis, C Bilodeau, J Wang, D Luo, M Asgari… - Stem Cell Research & …, 2024 - Springer
Background Chronic lung disease of prematurity, called bronchopulmonary dysplasia
(BPD), lacks effective therapies, stressing the need for preclinical testing systems that reflect …
(BPD), lacks effective therapies, stressing the need for preclinical testing systems that reflect …
Host defense against Klebsiella pneumoniae pneumonia is augmented by lung-derived mesenchymal stem cells
Klebsiella pneumoniae is a common cause of Gram-negative pneumonia. The spread of
antibiotic-resistant and hypervirulent strains has made treatment more challenging. This …
antibiotic-resistant and hypervirulent strains has made treatment more challenging. This …
[PDF][PDF] 3D Bioprinitng technologies for the enhancement and application of functional lung organoid models
J Jang, J Lee, S Cha, M Lee… - International Journal …, 2024 - api-journal.accscience.com
Respiratory diseases, ranging from minor infections to serious chronic diseases and
malignancies, negatively affect the respiratory system and are influenced by various …
malignancies, negatively affect the respiratory system and are influenced by various …
Lung Organoids: Systematic Review of Recent Advancements and its Future Perspectives
T Thangam, K Parthasarathy, K Supraja… - Tissue Engineering and …, 2024 - Springer
Organoids are essentially an in vitro (lab-grown) three-dimensional tissue culture system
model that meticulously replicates the structure and physiology of human organs. A few of …
model that meticulously replicates the structure and physiology of human organs. A few of …
[HTML][HTML] Comparative Analysis of Molecular Pathogenic Mechanisms and Antiviral Development Targeting Old and New World Hantaviruses
AV Jeyachandran, JI Irudayam, S Dubey… - bioRxiv, 2023 - ncbi.nlm.nih.gov
Background: Hantaviruses–dichotomized into New World (ie Andes virus, ANDV; Sin
Nombre virus, SNV) and Old-World viruses (ie Hantaan virus, HTNV)–are zoonotic viruses …
Nombre virus, SNV) and Old-World viruses (ie Hantaan virus, HTNV)–are zoonotic viruses …