Wounds are one of the most common health issues, and the cost of wound care and healing
has continued to increase over the past decade. The first step in wound healing is …

Hemorrhage is the leading cause of preventable death in combat trauma and the secondary
cause of death in civilian trauma. A significant number of deaths due to hemorrhage occur …

Abstract Development of functional nanoparticles can be encumbered by unanticipated
material properties and biological events, which can affect nanoparticle effectiveness in …

Solution self-assembly of block copolymers (BCPs) typically generates spheres, rods, and
vesicles. The reproducible bottom-up fabrication of stable planar nanostructures remains …

Severe hemorrhage has posed a serious threat to the health and even life of civilian and
military populations and brought serious economic losses. Consequently, it is imperative to …

To optimally penetrate biological hydrogels such as mucus and the tumor interstitial matrix,
nanoparticles (NPs) require physicochemical properties that would typically preclude …

Targeted delivery of therapeutic and imaging agents in the vascular compartment represents
a significant hurdle in using nanomedicine for treating hemorrhage, thrombosis, and …

Treatment of bleeding disorders using transfusion of donor-derived platelets faces logistical
challenges due to their limited availability, high risk of contamination, and short (5 to 7 days) …

Platelets play a vital physiological role in hemostasis, inflammation and tissue regeneration,
which are associated with wound healing as well as cancer development and metastasis …

Uncontrolled noncompressible hemorrhage is a major cause of mortality following traumatic
injuries in civilian and military populations. An injectable hemostat for point-of-care treatment …