Strategies for controlling the innate immune activity of conventional and self-amplifying mRNA therapeutics: Getting the message across
AK Minnaert, H Vanluchene, R Verbeke… - Advanced drug delivery …, 2021 - Elsevier
The recent approval of messenger RNA (mRNA)-based vaccines to combat the SARS-CoV-
2 pandemic highlights the potential of both conventional mRNA and self-amplifying mRNA …
2 pandemic highlights the potential of both conventional mRNA and self-amplifying mRNA …
mRNA therapeutics deliver a hopeful message
Z Zhong, S Mc Cafferty, F Combes, H Huysmans… - Nano today, 2018 - Elsevier
Messenger RNA based therapeutics have the potential to cause a big revolution in medicine
as they can facilitate personalized medicines and allow patients to produce their own …
as they can facilitate personalized medicines and allow patients to produce their own …
LY6E impairs coronavirus fusion and confers immune control of viral disease
Zoonotic coronaviruses (CoVs) are substantial threats to global health, as exemplified by the
emergence of two severe acute respiratory syndrome CoVs (SARS-CoV and SARS-CoV-2) …
emergence of two severe acute respiratory syndrome CoVs (SARS-CoV and SARS-CoV-2) …
A diverse range of gene products are effectors of the type I interferon antiviral response
JW Schoggins, SJ Wilson, M Panis, MY Murphy… - Nature, 2011 - nature.com
The type I interferon response protects cells against invading viral pathogens. The cellular
factors that mediate this defence are the products of interferon-stimulated genes (ISGs) …
factors that mediate this defence are the products of interferon-stimulated genes (ISGs) …
IFITM3 directly engages and shuttles incoming virus particles to lysosomes
Interferon-induced transmembrane proteins (IFITMs 1, 2 and 3) have emerged as important
innate immune effectors that prevent diverse virus infections in vertebrates. However, the …
innate immune effectors that prevent diverse virus infections in vertebrates. However, the …
[HTML][HTML] Efficient generation of human iPSCs by a synthetic self-replicative RNA
The generation of human induced pluripotent stem cells (iPSCs) holds great promise for the
development of regenerative medicine therapies to treat a wide range of human diseases …
development of regenerative medicine therapies to treat a wide range of human diseases …
Mammalian synthetic circuits with RNA binding proteins for RNA-only delivery
Synthetic regulatory circuits encoded in RNA rather than DNA could provide a means to
control cell behavior while avoiding potentially harmful genomic integration in therapeutic …
control cell behavior while avoiding potentially harmful genomic integration in therapeutic …
New World and Old World alphaviruses have evolved to exploit different components of stress granules, FXR and G3BP proteins, for assembly of viral replication …
DY Kim, JM Reynaud, A Rasalouskaya… - PLoS …, 2016 - journals.plos.org
The positive-strand RNA viruses initiate their amplification in the cell from a single genome
delivered by virion. This single RNA molecule needs to become involved in replication …
delivered by virion. This single RNA molecule needs to become involved in replication …
A dual-antigen self-amplifying RNA SARS-CoV-2 vaccine induces potent humoral and cellular immune responses and protects against SARS-CoV-2 variants through …
S McCafferty, AKMA Haque, A Vandierendonck… - Molecular Therapy, 2022 - cell.com
Self-amplifying RNA vaccines may induce equivalent or more potent immune responses at
lower doses compared to non-replicating mRNA vaccines via amplified antigen expression …
lower doses compared to non-replicating mRNA vaccines via amplified antigen expression …
Evasion of the innate immune response: the Old World alphavirus nsP2 protein induces rapid degradation of Rpb1, a catalytic subunit of RNA polymerase II
ABSTRACT The Old World alphaviruses are emerging human pathogens with an ability to
cause widespread epidemics. The latest epidemic of Chikungunya virus, from 2005 to 2007 …
cause widespread epidemics. The latest epidemic of Chikungunya virus, from 2005 to 2007 …