Malignant hyperthermia (MH) is a pharmacogenetic disorder of skeletal muscle that presents
as a hypermetabolic response to potent volatile anesthetic gases such as halothane …

Abstract Calcium (Ca 2+) signaling is critical for cell function and cell survival. Mitochondria
play a major role in regulating the intracellular Ca 2+ concentration ([Ca 2+] i). Mitochondrial …

The endoplasmic reticulum (ER) as an intracellular Ca2+ store not only sets up cytosolic
Ca2+ signals, but, among other functions, also assembles and folds newly synthesized …

Mitochondria are strategically and dynamically positioned in the cell to spatially coordinate
ATP production with energy needs and to allow the local exchange of material with other …

Ryanodine receptor type 1-related myopathies (RYR1-RM) are the most common class of
congenital myopathies. Historically, RYR1-RM classification and diagnosis have been …

Homeostatic control of the endoplasmic reticulum (ER) both as the site for protein handling
(synthesis, folding, trafficking, disaggregation and degradation) and as a Ca2+ store is of …

Molecular targets to reduce muscle weakness and atrophy due to oxidative stress have
been elusive. Here we show that activation of Sarcoplasmic Reticulum (SR) Ca 2+ ATPase …

TRIM family proteins play integral roles in the innate immune response to virus infection.
MG53 (TRIM72) is essential for cell membrane repair and is believed to be a muscle-specific …

Thermoregulation is an important aspect of human homeostasis, and high temperatures
pose serious stresses for the body. Malignant hyperthermia (MH) is a life-threatening …

Malignant hyperthermia (MH) susceptibility has been attributed to a leaky sarcoplasmic
reticulum (SR) caused by missense mutations in RYR1 or CACNA1S, and the MH crisis has …