Lipid droplet biogenesis and functions in health and disease

A Zadoorian, X Du, H Yang - Nature Reviews Endocrinology, 2023 - nature.com
Ubiquitous yet unique, lipid droplets are intracellular organelles that are increasingly being
recognized for their versatility beyond energy storage. Advances uncovering the intricacies …

Lipid droplets and liver disease: from basic biology to clinical implications

NL Gluchowski, M Becuwe, TC Walther… - Nature reviews …, 2017 - nature.com
Lipid droplets are dynamic organelles that store neutral lipids during times of energy excess
and serve as an energy reservoir during deprivation. Many prevalent metabolic diseases …

Lipid droplet biogenesis

TC Walther, J Chung… - Annual review of cell and …, 2017 - annualreviews.org
Lipid droplets (LDs) are ubiquitous organelles that store neutral lipids for energy or
membrane synthesis and act as hubs for metabolic processes. Cells generate LDs de novo …

Macrophage‐mediated cholesterol handling in atherosclerosis

DA Chistiakov, YV Bobryshev… - Journal of cellular and …, 2016 - Wiley Online Library
Formation of foam cells is a hallmark at the initial stages of atherosclerosis. Monocytes
attracted by pro‐inflammatory stimuli attach to the inflamed vascular endothelium and …

Emerging risk biomarkers in cardiovascular diseases and disorders

RK Upadhyay - Journal of lipids, 2015 - Wiley Online Library
Present review article highlights various cardiovascular risk prediction biomarkers by
incorporating both traditional risk factors to be used as diagnostic markers and recent …

[HTML][HTML] Thematic review series: glycerolipids. DGAT enzymes and triacylglycerol biosynthesis

CLE Yen, SJ Stone, S Koliwad, C Harris… - Journal of lipid …, 2008 - Elsevier
Triacylglycerols (triglycerides)(TGs) are the major storage molecules of metabolic energy
and FAs in most living organisms. Excessive accumulation of TGs, however, is associated …

Intestinal lipid absorption

J Iqbal, MM Hussain - American Journal of Physiology …, 2009 - journals.physiology.org
Our knowledge of the uptake and transport of dietary fat and fat-soluble vitamins has
advanced considerably. Researchers have identified several new mechanisms by which …

Oxysterols: modulators of cholesterol metabolism and other processes

GJ Schroepfer Jr - Physiological reviews, 2000 - journals.physiology.org
Oxygenated derivatives of cholesterol (oxysterols) present a remarkably diverse profile of
biological activities, including effects on sphingolipid metabolism, platelet aggregation …

Acyl-coenzyme A: cholesterol acyltransferases

TY Chang, BL Li, CCY Chang… - American Journal of …, 2009 - journals.physiology.org
The enzymes acyl-coenzyme A (CoA): cholesterol acyltransferases (ACATs) are membrane-
bound proteins that utilize long-chain fatty acyl-CoA and cholesterol as substrates to form …

Acyl-CoA: diacylglycerol acyltransferase: molecular biology, biochemistry and biotechnology

Q Liu, RMP Siloto, R Lehner, SJ Stone… - Progress in lipid …, 2012 - Elsevier
Triacylglycerol (TG) is a storage lipid which serves as an energy reservoir and a source of
signalling molecules and substrates for membrane biogenesis. TG is essential for many …