Historically, natural plant-derived drugs received a great impact of consideration in the
treatment of several human-associated disorders. Cancer is a devastating disease and the …

Benzophenanthridine alkaloids are a class of isoquinoline compounds, which are widely
found in the plants of papaveraceae, corydalis, and rutaceae. Biological activities and …

Grape pomace (GP)—the major by-product of winemaking processes—still contains
bioactive molecules with known beneficial properties for human health, such as an …

Because the use of antibiotics is forbidden, piglets experience a considerable weanling
stress, resulting in increased incidence of diarrhea and death. Macleaya cordata extract or …

Tumor cells employ multiple signaling mediators to escape the hypoxic condition and trigger
angiogenesis and metastasis. As a critical orchestrate of tumorigenic conditions, hypoxia …

Sanguinarine is a quaternary ammonium benzophenanthine alkaloid found in traditional
herbs such as Chelidonium, Corydalis, Sanguinarum, and Borovula. It has been proven to …

Colorectal cancer (CRC) is the third most commonly diagnosed cancer worldwide, with 20%
of patients presenting with metastatic disease at diagnosis. TGF-β signaling plays a crucial …

Glioblastomas (GBMs) represent the most aggressive form of brain tumor arising from the
malignant transformation of astrocytes. Despite various advancements, treatment options …

Breast cancer (BC) is a highly debilitating malignancy affecting females globally and
imposing a substantial burden on healthcare systems in both developed and developing …

Breast cancer (BC) is one of the leading causes of cancer-related deaths in women
worldwide. The tumor microenvironment (TME) plays a crucial role in the progression and …