[HTML][HTML] Vaccination in the elderly: the challenge of immune changes with aging

A Ciabattini, C Nardini, F Santoro, P Garagnani… - Seminars in …, 2018 - Elsevier
The unprecedented increase of life expectancy challenges society to protect the elderly from
morbidity and mortality making vaccination a crucial mean to safeguard this population …

IL‐10: a multifunctional cytokine in viral infections

JM Rojas, M Avia, V Martín… - Journal of immunology …, 2017 - Wiley Online Library
The anti‐inflammatory master regulator IL‐10 is critical to protect the host from tissue
damage during acute phases of immune responses. This regulatory mechanism, central to T …

Cytomegalovirus: shape-shifting the immune system

G Picarda, CA Benedict - The Journal of Immunology, 2018 - journals.aai.org
Abstract Systems-based based approaches have begun to shed light on extrinsic factors that
contribute to immune system variation. Among these, CMV (HHV-5, a β-herpesvirus) …

Early IL-6 signalling promotes IL-27 dependent maturation of regulatory T cells in the lungs and resolution of viral immunopathology

CJ Pyle, FI Uwadiae, DP Swieboda, JA Harker - PLoS pathogens, 2017 - journals.plos.org
Interleukin-6 is a pleiotropic, pro-inflammatory cytokine that can promote both innate and
adaptive immune responses. In humans with respiratory virus infections, such as …

Immune surveillance of cytomegalovirus in tissues

A Mihalić, J Železnjak, B Lisnić, S Jonjić… - Cellular & molecular …, 2024 - nature.com
Cytomegalovirus (CMV), a representative member of the Betaherpesvirinae subfamily of
herpesviruses, is common in the human population, but immunocompetent individuals are …

Herpesvirus‐bacteria synergistic interaction in periodontitis

C Chen, P Feng, J Slots - Periodontology 2000, 2020 - Wiley Online Library
The etiopathogenesis of severe periodontitis includes herpesvirus‐bacteria coinfection. This
article evaluates the pathogenicity of herpesviruses (cytomegalovirus and Epstein‐Barr …

The CD4+ T cell response to human cytomegalovirus in healthy and immunocompromised people

EY Lim, SE Jackson, MR Wills - Frontiers in cellular and infection …, 2020 - frontiersin.org
While CD8+ T cells specific for human cytomegalovirus (HCMV) have been extensively
studied in both healthy HCMV seropositive carriers and patients undergoing …

Latent cytomegalovirus (CMV) infection does not detrimentally alter T cell responses in the healthy old, but increased latent CMV carriage is related to expanded CMV …

SE Jackson, GX Sedikides, G Okecha… - Frontiers in …, 2017 - frontiersin.org
Human cytomegalovirus (HCMV) primary infection and periodic reactivation of latent virus is
generally well controlled by T-cell responses in healthy people. In older donors, overt HCMV …

Antiviral activities of interleukin-27: a partner for interferons?

H Amsden, O Kourko, M Roth, K Gee - Frontiers in Immunology, 2022 - frontiersin.org
Emergence of new, pandemic-level viral threats has brought to the forefront the importance
of viral immunology and continued improvement of antiviral therapies. Interleukin-27 (IL-27) …

Aging and options to halt declining immunity to virus infections

MÁ Palacios-Pedrero, ADME Osterhaus… - Frontiers in …, 2021 - frontiersin.org
Immunosenescence is a process associated with aging that leads to dysregulation of cells of
innate and adaptive immunity, which may become dysfunctional. Consequently, older adults …