Importance Epilepsy affects approximately 65 million people worldwide. Persistent seizures
are associated with a 20% to 40% risk of bodily injuries (eg, fractures, burns, concussions) …

Three decades after its introduction as an adjuvant therapeutic option in the management of
selective drug-resistant epilepsy cases (DRE), vagus nerve stimulation (VNS) retains …

Progressive functional decline in the epilepsies is largely unexplained. We formed the
ENIGMA-Epilepsy consortium to understand factors that influence brain measures in …

Epilepsy affects 65 million people worldwide and entails a major burden in seizure-related
disability, mortality, comorbidities, stigma, and costs. In the past decade, important advances …

Brain and viscera interplay within the autonomic nervous system where the vagus nerve
(VN), containing approximately 80% afferent and 20% efferent fibres, plays multiple key …

Summary The International League Against Epilepsy has recently published a new
classification of epileptic seizures and epilepsies to reflect the major scientific advances in …

Aim The neural cardiac therapy for heart failure (NECTAR-HF) was a randomized sham-
controlled trial designed to evaluate whether a single dose of vagal nerve stimulation (VNS) …

Approximately 50 million people worldwide suffer from epilepsy, and approximately 30% to
40% of these persons have seizures that are refractory to treatment with antiepileptic …

Vagus nerve stimulation (VNS) has emerged as a therapy to treat a wide range of
neurological disorders, including epilepsy, depression, stroke, and tinnitus. Activation of …

BACKGROUND: Neuromodulation-based treatments have become increasingly important in
epilepsy treatment. Most patients with epilepsy treated with neuromodulation do not achieve …