Serology as a tool to assess infectious disease landscapes and guide public health policy

AH Haselbeck, J Im, K Prifti, F Marks, M Holm… - Pathogens, 2022 - mdpi.com
Understanding the local burden and epidemiology of infectious diseases is crucial to guide
public health policy and prioritize interventions. Typically, infectious disease surveillance …

Germline-encoded amino acid–binding motifs drive immunodominant public antibody responses

EL Shrock, RT Timms, T Kula, EL Mena, AP West Jr… - Science, 2023 - science.org
Despite the vast diversity of the antibody repertoire, infected individuals often mount
antibody responses to precisely the same epitopes within antigens. The immunological …

The insider: impact of the gut microbiota on cancer immunity and response to therapies in multiple myeloma

A Brevi, LL Cogrossi, M Lorenzoni, B Mattorre… - Frontiers in …, 2022 - frontiersin.org
The human microbiota is a unique set of microorganisms colonizing the human body and
evolving within it from the very beginning. Acting as an insider, the microbiota provides …

The systemic anti-microbiota IgG repertoire can identify gut bacteria that translocate across gut barrier surfaces

I Vujkovic-Cvijin, HC Welles, CWY Ha, L Huq… - Science translational …, 2022 - science.org
Unique gut microbiota compositions have been associated with inflammatory diseases, but
identifying gut bacterial functions linked to immune activation in humans remains …

Systemic antibody responses against human microbiota flagellins are overrepresented in chronic fatigue syndrome patients

T Vogl, IN Kalka, S Klompus, S Leviatan… - Science …, 2022 - science.org
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating disease with
an unclear etiology and pathogenesis. Both an involvement of the immune system and gut …

Phage-display immunoprecipitation sequencing of the antibody epitope repertoire in inflammatory bowel disease reveals distinct antibody signatures

AR Bourgonje, S Andreu-Sánchez, T Vogl, S Hu… - Immunity, 2023 - cell.com
Inflammatory bowel diseases (IBDs), eg, Crohn's disease (CD) and ulcerative colitis (UC),
are chronic immune-mediated inflammatory diseases. A comprehensive overview of an IBD …

Autoantibody discovery across monogenic, acquired, and COVID-19-associated autoimmunity with scalable PhIP-seq

SE Vazquez, SA Mann, A Bodansky, AF Kung… - Elife, 2022 - elifesciences.org
Phage immunoprecipitation sequencing (PhIP-seq) allows for unbiased, proteome-wide
autoantibody discovery across a variety of disease settings, with identification of disease …

Phage ImmunoPrecipitation Sequencing (PhIP-Seq): the promise of high throughput serology

CK Tiu, F Zhu, LF Wang, R de Alwis - Pathogens, 2022 - mdpi.com
Simple Summary Determining the exposure or infection history of a person to a multitude of
viruses is not an easy task. Typically, antibody tests detect antibodies against proteins …

Microecosystem of yak rumen on the Qinghai‐Tibetan Plateau is stable and is unaffected by soil or grass microbiota

Q Fan, K Xie, X Cui, G Zhang, H Zheng… - Environmental …, 2022 - Wiley Online Library
The rumen of livestock grazing on the Qinghai‐Tibetan Plateau (QTP) acts as a transfer
station for the circulation of soil, grass, faecal mineral elements and nutrients. Whether the …

Intergenerational protective anti-gut commensal immunoglobulin G originates in early life

B Rusconi, AK Bard, R McDonough… - Proceedings of the …, 2024 - National Acad Sciences
Maternal immunoglobulins of the class G (IgGs) protect offspring from enteric infection, but
when, where, and how these antibodies are physiologically generated and confer protection …