Understanding histone H3 lysine 36 methylation and its deregulation in disease
Methylation of histone H3 lysine 36 (H3K36) plays crucial roles in the partitioning of
chromatin to distinctive domains and the regulation of a wide range of biological processes …
chromatin to distinctive domains and the regulation of a wide range of biological processes …
The role of NSD1, NSD2, and NSD3 histone methyltransferases in solid tumors
Abstract NSD1, NSD2, and NSD3 constitute the nuclear receptor-binding SET Domain
(NSD) family of histone 3 lysine 36 (H3K36) methyltransferases. These structurally similar …
(NSD) family of histone 3 lysine 36 (H3K36) methyltransferases. These structurally similar …
Molecular basis of nucleosomal H3K36 methylation by NSD methyltransferases
Histone methyltransferases of the nuclear receptor-binding SET domain protein (NSD)
family, including NSD1, NSD2 and NSD3, have crucial roles in chromatin regulation and are …
family, including NSD1, NSD2 and NSD3, have crucial roles in chromatin regulation and are …
Discovery of a potent and selective targeted NSD2 degrader for the reduction of H3K36me2
RP Hanley, DY Nie, JR Tabor, F Li… - Journal of the …, 2023 - ACS Publications
Nuclear receptor-binding SET domain-containing 2 (NSD2) plays important roles in gene
regulation, largely through its ability to dimethylate lysine 36 of histone 3 (H3K36me2) …
regulation, largely through its ability to dimethylate lysine 36 of histone 3 (H3K36me2) …
Covalent inhibition of NSD1 histone methyltransferase
The nuclear receptor-binding SET domain (NSD) family of histone methyltransferases is
associated with various malignancies, including aggressive acute leukemia with NUP98 …
associated with various malignancies, including aggressive acute leukemia with NUP98 …
[HTML][HTML] An OpenData portal to share COVID-19 drug repurposing data in real time
Abstract The National Center for Advancing Translational Sciences (NCATS) has developed
an online open science data portal for its COVID-19 drug repurposing campaign–named …
an online open science data portal for its COVID-19 drug repurposing campaign–named …
Discovery of a first-in-class degrader for nuclear receptor binding SET domain protein 2 (NSD2) and Ikaros/Aiolos
Overexpression of nuclear receptor binding SET domain protein 2 (NSD2) is frequent in
multiple myeloma (MM). However, existing NSD2 inhibitors are largely ineffective in …
multiple myeloma (MM). However, existing NSD2 inhibitors are largely ineffective in …
Hydrophobic tag tethering degrader as a promising paradigm of protein degradation: past, present and future perspectives
S Ha, J Zhu, H Xiang, G Luo - Chinese Chemical Letters, 2024 - Elsevier
Small molecule inhibitors have dominated the pharmaceutical landscape for a long time as
the primary therapeutic paradigm targeting pathogenic proteins. However, their efficacy …
the primary therapeutic paradigm targeting pathogenic proteins. However, their efficacy …
Drug discovery targeting nuclear receptor binding SET domain protein 2 (NSD2)
Nuclear receptor binding SET domain proteins (NSDs) catalyze the mono-or dimethylation
of histone 3 lysine 36 (H3K36me1 and H3K36me2), using S-adenosyl-l-methionine (SAM) …
of histone 3 lysine 36 (H3K36me1 and H3K36me2), using S-adenosyl-l-methionine (SAM) …
Nuisance compounds in cellular assays
JL Dahlin, DS Auld, I Rothenaigner, S Haney… - Cell chemical …, 2021 - cell.com
Compounds that exhibit assay interference or undesirable mechanisms of bioactivity ("
nuisance compounds") are routinely encountered in cellular assays, including phenotypic …
nuisance compounds") are routinely encountered in cellular assays, including phenotypic …