Human autoantibodies underlying infectious diseases
A Puel, P Bastard, J Bustamante… - Journal of Experimental …, 2022 - rupress.org
The vast interindividual clinical variability observed in any microbial infection—ranging from
silent infection to lethal disease—is increasingly being explained by human genetic and …
silent infection to lethal disease—is increasingly being explained by human genetic and …
Pathogenesis of respiratory viral and fungal coinfections
Individuals suffering from severe viral respiratory tract infections have recently emerged as
“at risk” groups for developing invasive fungal infections. Influenza virus is one of the most …
“at risk” groups for developing invasive fungal infections. Influenza virus is one of the most …
The cGAS–STING pathway drives type I IFN immunopathology in COVID-19
JD Domizio, MF Gulen, F Saidoune, VV Thacker… - Nature, 2022 - nature.com
COVID-19, which is caused by infection with SARS-CoV-2, is characterized by lung
pathology and extrapulmonary complications,. Type I interferons (IFNs) have an essential …
pathology and extrapulmonary complications,. Type I interferons (IFNs) have an essential …
Neuropilin-1 mediates SARS-CoV-2 infection of astrocytes in brain organoids, inducing inflammation leading to dysfunction and death of neurons
ABSTRACT Coronavirus disease 2019 (COVID-19) is frequently associated with
neurological deficits, but how severe acute respiratory syndrome coronavirus 2 (SARS-CoV …
neurological deficits, but how severe acute respiratory syndrome coronavirus 2 (SARS-CoV …
The RNA sensor MDA5 detects SARS-CoV-2 infection
Human cells respond to infection by SARS-CoV-2, the virus that causes COVID-19, by
producing cytokines including type I and III interferons (IFNs) and proinflammatory factors …
producing cytokines including type I and III interferons (IFNs) and proinflammatory factors …
[HTML][HTML] Humans with inherited MyD88 and IRAK-4 deficiencies are predisposed to hypoxemic COVID-19 pneumonia
A García-García, R Pérez de Diego, C Flores… - Journal of Experimental …, 2023 - rupress.org
Disclosures: C. Flores reported grants from Instituto de Salud Carlos III, Spanish Ministry of
Science and Innovation, and Cabildo Insular de Tenerife outside the submitted work. J …
Science and Innovation, and Cabildo Insular de Tenerife outside the submitted work. J …
SARS-CoV-2 disrupts proximal elements in the JAK-STAT pathway
ABSTRACT SARS-CoV-2 can infect multiple organs, including lung, intestine, kidney, heart,
liver, and brain. The molecular details of how the virus navigates through diverse cellular …
liver, and brain. The molecular details of how the virus navigates through diverse cellular …
Respiratory viral infections in otherwise healthy humans with inherited IRF7 deficiency
Autosomal recessive IRF7 deficiency was previously reported in three patients with single
critical influenza or COVID-19 pneumonia episodes. The patients' fibroblasts and …
critical influenza or COVID-19 pneumonia episodes. The patients' fibroblasts and …
Human type I IFN deficiency does not impair B cell response to SARS-CoV-2 mRNA vaccination
A Sokal, P Bastard, P Chappert… - Journal of Experimental …, 2022 - rupress.org
Inborn and acquired deficits of type I interferon (IFN) immunity predispose to life-threatening
COVID-19 pneumonia. We longitudinally profiled the B cell response to mRNA vaccination …
COVID-19 pneumonia. We longitudinally profiled the B cell response to mRNA vaccination …
Immunoglobulin germline gene polymorphisms influence the function of SARS-CoV-2 neutralizing antibodies
P Pushparaj, A Nicoletto, DJ Sheward, H Das… - Immunity, 2023 - cell.com
The human immunoglobulin heavy-chain (IGH) locus is exceptionally polymorphic, with high
levels of allelic and structural variation. Thus, germline IGH genotypes are personal, which …
levels of allelic and structural variation. Thus, germline IGH genotypes are personal, which …