Brain aging is a complex process that affects everything from the subcellular to the organ
level, begins early in life, and accelerates with age. Morphologically, brain aging is primarily …

White matter makes up about fifty percent of the human brain. Maturation of white matter
accompanies biological development and undergoes the most dramatic changes during …

We present a review of the characterization of healthy brain aging using MRI with an
emphasis on morphology, lesions, and quantitative MR parameters. A scope review found …

Alzheimer's disease (AD) is a neurodegenerative disorder with neuronal and synaptic
losses due to the accumulation of toxic amyloid β (Αβ) peptide oligomers, plaques, and …

White matter (WM) microstructural properties change across the adult lifespan and with
neuronal diseases. Understanding microstructural changes due to aging is paramount to …

Myelin loss and iron accumulation are cardinal features of aging and various
neurodegenerative diseases. Oligodendrocytes incorporate iron as a metabolic substrate for …

The interaction between ageing and multiple sclerosis is complex and carries significant
implications for patient care. Managing multiple sclerosis effectively requires an …

Demyelination occurs in response to brain injury and is observed in many
neurodegenerative diseases. Myelin is synthesized from oligodendrocytes in the central …

Cellular senescence is a highly complicated cellular state that occurs throughout the
lifespan of an organism. It has been well-defined in mitotic cells by various senescent …

Progress made by the medical community in increasing lifespans comes with the costs of
increasing the incidence and prevalence of age-related diseases, neurodegenerative ones …