Rodent models for Alzheimer's disease drug discovery
D Puzzo, W Gulisano, A Palmeri… - Expert opinion on drug …, 2015 - Taylor & Francis
Introduction: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by
memory loss and personality changes, leading to dementia. Histopathological hallmarks are …
memory loss and personality changes, leading to dementia. Histopathological hallmarks are …
Amyloid precursor protein (APP) and amyloid β (Aβ) interact with cell adhesion molecules: Implications in Alzheimer's disease and normal physiology
Alzheimer's disease (AD) is an incurable neurodegenerative disorder in which dysfunction
and loss of synapses and neurons lead to cognitive impairment and death. Accumulation …
and loss of synapses and neurons lead to cognitive impairment and death. Accumulation …
[HTML][HTML] Co-expression network analysis identified hub genes critical to triglyceride and free fatty acid metabolism as key regulators of age-related vascular …
Background: Aging has often been linked to age-related vascular disorders. The elucidation
of the putative genes and pathways underlying vascular aging likely provides useful insights …
of the putative genes and pathways underlying vascular aging likely provides useful insights …
Contactins in the central nervous system: role in health and disease
M Chatterjee, D Schild… - Neural regeneration …, 2019 - journals.lww.com
Contactins are a group of cell adhesion molecules that are mainly expressed in the brain
and play pivotal roles in the organization of axonal domains, axonal guidance …
and play pivotal roles in the organization of axonal domains, axonal guidance …
[HTML][HTML] Genetic deletion of α7 nicotinic acetylcholine receptors induces an age-dependent Alzheimer's disease-like pathology
MR Tropea, DDL Puma, M Melone, W Gulisano… - Progress in …, 2021 - Elsevier
The accumulation of amyloid-beta peptide (Aβ) and the failure of cholinergic transmission
are key players in Alzheimer's disease (AD). However, in the healthy brain, Aβ contributes to …
are key players in Alzheimer's disease (AD). However, in the healthy brain, Aβ contributes to …
Revisiting rodent models: Octodon degus as Alzheimer's disease model?
J Steffen, M Krohn, K Paarmann, C Schwitlick… - Acta neuropathologica …, 2016 - Springer
Alzheimer's disease primarily occurs as sporadic disease and is accompanied with vast
socio-economic problems. The mandatory basic research relies on robust and reliable …
socio-economic problems. The mandatory basic research relies on robust and reliable …
Glycosylphosphatidylinositol-anchored immunoglobulin superfamily cell adhesion molecules and their role in neuronal development and synapse regulation
RPA Tan, I Leshchyns' ka, V Sytnyk - Frontiers in molecular …, 2017 - frontiersin.org
Immunoglobulin superfamily (IgSF) cell adhesion molecules (CAMs) are cell surface
glycoproteins that not only mediate interactions between neurons but also between neurons …
glycoproteins that not only mediate interactions between neurons but also between neurons …
The interaction between contactin and amyloid precursor protein and its role in Alzheimer's disease
RA Bamford, J Widagdo, N Takamura, M Eve… - Neuroscience, 2020 - Elsevier
Alzheimer's disease (AD) is a debilitating disease and the most common cause of dementia.
As the world population ages even modest advances in therapies and preventative …
As the world population ages even modest advances in therapies and preventative …
The antineoplastic drug flavopiridol reverses memory impairment induced by Amyloid-ß1-42 oligomers in mice
The ectopic re-activation of cell cycle in neurons is an early event in the pathogenesis of
Alzheimer's disease (AD), which could lead to synaptic failure and ensuing cognitive deficits …
Alzheimer's disease (AD), which could lead to synaptic failure and ensuing cognitive deficits …
The role of Contactin 1 in cancers: what we know so far
Y Liang, C Ma, F Li, G Nie, H Zhang - Frontiers in Oncology, 2020 - frontiersin.org
Cancers are among the difficult-to-treat diseases despite advances in diagnosis and
treatment. Although newer effective targets remain to be discovered, targeted therapy has …
treatment. Although newer effective targets remain to be discovered, targeted therapy has …