Rodent models for Alzheimer's disease drug discovery

D Puzzo, W Gulisano, A Palmeri… - Expert opinion on drug …, 2015 - Taylor & Francis
Introduction: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by
memory loss and personality changes, leading to dementia. Histopathological hallmarks are …

Amyloid precursor protein (APP) and amyloid β (Aβ) interact with cell adhesion molecules: Implications in Alzheimer's disease and normal physiology

G Pfundstein, AG Nikonenko, V Sytnyk - Frontiers in cell and …, 2022 - frontiersin.org
Alzheimer's disease (AD) is an incurable neurodegenerative disorder in which dysfunction
and loss of synapses and neurons lead to cognitive impairment and death. Accumulation …

[HTML][HTML] Co-expression network analysis identified hub genes critical to triglyceride and free fatty acid metabolism as key regulators of age-related vascular …

H Li, X Wang, X Lu, H Zhu, S Li, S Duan, X Zhao… - Aging (Albany …, 2019 - ncbi.nlm.nih.gov
Background: Aging has often been linked to age-related vascular disorders. The elucidation
of the putative genes and pathways underlying vascular aging likely provides useful insights …

Contactins in the central nervous system: role in health and disease

M Chatterjee, D Schild… - Neural regeneration …, 2019 - journals.lww.com
Contactins are a group of cell adhesion molecules that are mainly expressed in the brain
and play pivotal roles in the organization of axonal domains, axonal guidance …

[HTML][HTML] Genetic deletion of α7 nicotinic acetylcholine receptors induces an age-dependent Alzheimer's disease-like pathology

MR Tropea, DDL Puma, M Melone, W Gulisano… - Progress in …, 2021 - Elsevier
The accumulation of amyloid-beta peptide (Aβ) and the failure of cholinergic transmission
are key players in Alzheimer's disease (AD). However, in the healthy brain, Aβ contributes to …

Revisiting rodent models: Octodon degus as Alzheimer's disease model?

J Steffen, M Krohn, K Paarmann, C Schwitlick… - Acta neuropathologica …, 2016 - Springer
Alzheimer's disease primarily occurs as sporadic disease and is accompanied with vast
socio-economic problems. The mandatory basic research relies on robust and reliable …

Glycosylphosphatidylinositol-anchored immunoglobulin superfamily cell adhesion molecules and their role in neuronal development and synapse regulation

RPA Tan, I Leshchyns' ka, V Sytnyk - Frontiers in molecular …, 2017 - frontiersin.org
Immunoglobulin superfamily (IgSF) cell adhesion molecules (CAMs) are cell surface
glycoproteins that not only mediate interactions between neurons but also between neurons …

The interaction between contactin and amyloid precursor protein and its role in Alzheimer's disease

RA Bamford, J Widagdo, N Takamura, M Eve… - Neuroscience, 2020 - Elsevier
Alzheimer's disease (AD) is a debilitating disease and the most common cause of dementia.
As the world population ages even modest advances in therapies and preventative …

The antineoplastic drug flavopiridol reverses memory impairment induced by Amyloid-ß1-42 oligomers in mice

GM Leggio, MV Catania, D Puzzo, M Spatuzza… - Pharmacological …, 2016 - Elsevier
The ectopic re-activation of cell cycle in neurons is an early event in the pathogenesis of
Alzheimer's disease (AD), which could lead to synaptic failure and ensuing cognitive deficits …

The role of Contactin 1 in cancers: what we know so far

Y Liang, C Ma, F Li, G Nie, H Zhang - Frontiers in Oncology, 2020 - frontiersin.org
Cancers are among the difficult-to-treat diseases despite advances in diagnosis and
treatment. Although newer effective targets remain to be discovered, targeted therapy has …