Small GTPases use GDP/GTP alternation to actuate a variety of functional switches that are
pivotal for cell dynamics. The GTPase switch is turned on by GEFs, which stimulate …

Vision is the most fundamental of our senses initiated when photons are absorbed by the
rod and cone photoreceptor neurons of the retina. At the distal end of each photoreceptor …

Abstract Lipidated Rho and Rab GTP-binding proteins are transported between membranes
in complex with solubilizing factors called'guanine nucleotide dissociation inhibitors'(GDIs) …

The small GTPases from the Ras superfamily play crucial roles in basic cellular processes
during practically the entire process of neurodevelopment, including neurogenesis …

UNC119 is widely expressed among vertebrates and other phyla. We found that UNC119
recognized the acylated N terminus of the rod photoreceptor transducin α (Tα) subunit and …

Intraflagellar transport (IFT) machinery mediates the bidirectional movement of cargos that
are required for the assembly and maintenance of cilia. However, little is known about how …

Arf-like protein 3 (ARL3) is a ubiquitous small GTPase expressed in ciliated cells of plants
and animals. Germline deletion of Arl3 in mice causes multiorgan ciliopathy reminiscent of …

Ciliary trafficking defects are the underlying cause of many ciliopathies, including Retinitis
Pigmentosa (RP). Anterograde intraflagellar transport (IFT) is mediated by kinesin motor …

Ciliary receptors and their certain downstream signaling components undergo intraflagellar
transport (IFT) as BBSome cargoes to maintain their ciliary dynamics for sensing and …

Pathological alterations of the Golgi apparatus, such as its fragmentation represent an early
pre-clinical feature of many neurodegenerative diseases and have been widely studied in …