Complement deficient cases reported in the second half of the last century have been of
great help in defining the role of complement in host defence. Surveys of the deficient …

Mannan-binding lectin (MBL), L-ficolin, M-ficolin and H-ficolin are all complement activating
soluble pattern recognition molecules with recognition domains linked to collagen-like …

Background. The purpose of our study was to evaluate the incidence and clinical
characteristics of febrile episodes during neutropenia following chemotherapy in children …

Recent studies have revealed profound developmental consequences of mutations in genes
encoding proteins of the lectin pathway of complement activation, a central component of the …

As more original molecular protocols and subsequent modifications are described in the
literature, it has become difficult for those not directly involved in the development of these …

This guideline aims to describe the complement system and the functions of the constituent
pathways, with particular focus on primary immunodeficiencies (PIDs) and their diagnosis …

Bloodstream infections (bacteraemia) account for approximately 25–30% of febrile episodes
in patients with febrile neutropenia (FN). In developed countries, Gram-positive pathogens …

An improved understanding of the pathogenesis of Aspergillus infections has facilitated the
identification of host biomarkers that, if validated in well-designed prospective studies, could …

Background. Invasive aspergillosis is a devastating infection with attributable mortality of
40% despite antifungal therapy. In animal models of aspergillosis, deficiency of mannose …

Background. The incidence of bacterial sepsis during the neonatal period is high. Mannan-
binding lectin (MBL), L-ficolin, and H-ficolin recognize microorganisms and activate the …