Fibrous stroma: Driver and passenger in cancer development
Cumulative evidence shows that fibrogenic stroma and stiff extracellular matrix (ECM) not
only result from tumor growth but also play pivotal roles in cellular transformation and tumor …
only result from tumor growth but also play pivotal roles in cellular transformation and tumor …
Characterising cancer-associated fibroblast heterogeneity in non-small cell lung cancer: a systematic review and meta-analysis
Cancer-associated fibroblasts (CAFs) are a key component of the tumour microenvironment
with evidence suggesting they represent a heterogeneous population. This study …
with evidence suggesting they represent a heterogeneous population. This study …
Pericentromeric satellite lncRNAs are induced in cancer-associated fibroblasts and regulate their functions in lung tumorigenesis
NI Enukashvily, NV Ponomartsev, A Ketkar… - Cell death & …, 2023 - nature.com
The abnormal tumor microenvironment (TME) often dictates the therapeutic response of
cancer to chemo-and immuno-therapy. Aberrant expression of pericentromeric satellite …
cancer to chemo-and immuno-therapy. Aberrant expression of pericentromeric satellite …
Remodeling of stromal cells and immune landscape in microenvironment during tumor progression
The molecular understanding of carcinogenesis and tumor progression rests in intra and
inter-tumoral heterogeneity. Solid tumors confined with vast diversity of genetic …
inter-tumoral heterogeneity. Solid tumors confined with vast diversity of genetic …
The biological and biomechanical role of transglutaminase-2 in the tumour microenvironment
R Tempest, S Guarnerio, R Maani, J Cooper, N Peake - Cancers, 2021 - mdpi.com
Simple Summary Transglutaminase-2 (TG2) is an enzyme primarily involved in protein cross-
linking, which has been shown to play a role in the development and progression of …
linking, which has been shown to play a role in the development and progression of …
T-cell tumour exclusion and immunotherapy resistance: a role for CAF targeting
Recent studies have highlighted a major role for cancer-associated fibroblasts (CAFs) in
promoting immunotherapy resistance by excluding T cells from tumours. Recently, we …
promoting immunotherapy resistance by excluding T cells from tumours. Recently, we …
The ferroxidase hephaestin in lung cancer: pathological significance and prognostic value
P Zacchi, B Belmonte, A Mangogna, G Morello… - Frontiers in …, 2021 - frontiersin.org
Hephaestin (HEPH) belongs to a group of exocytoplasmic ferroxidases which contribute to
cellular iron homeostasis by favouring its export. Down-regulation of HEPH expression …
cellular iron homeostasis by favouring its export. Down-regulation of HEPH expression …
Systems pharmacology: a combination strategy for improving efficacy of PD-1/PD-L1 blockade
C Zheng, Y Xiao, C Chen, J Zhu, R Yang… - Briefings in …, 2021 - academic.oup.com
Targeting tumor microenvironment (TME), such as immune checkpoint blockade (ICB), has
achieved increased overall response rates in many advanced cancers, such as non-small …
achieved increased overall response rates in many advanced cancers, such as non-small …