The absorption of oral drugs is frequently plagued by significant variability with potentially
serious therapeutic consequences. The source of variability can be traced back to …

Functional constipation is common in children and adults worldwide. Functional constipation
shows similarities in children and adults, but important differences also exist regarding …

Introduction Chronic constipation is highly prevalent, affecting between 10% and 15% of the
population. The Rome IV criteria categorizes disorders of chronic constipation into four …

The act of defaecation, although a ubiquitous human experience, requires the coordinated
actions of the anorectum and colon, pelvic floor musculature, and the enteric, peripheral and …

The extrinsic and autonomic nervous system intricately controls the major functions of the
gastrointestinal tract through the enteric nervous system; these include motor, secretory …

The growth of functional components containing agricultural foods is enhancing because
these components aid the human body against different chronic diseases. Currently, chia …

Chronic idiopathic constipation (CIC) is one of the most common gastrointestinal disorders,
with a global prevalence of 14%. It is commoner in women and its prevalence increases with …

Smooth muscle cells (SMCs) execute important physiological functions in numerous vital
organ systems, including the vascular, gastrointestinal, respiratory, and urogenital tracts …

Fruits are the seed-bearing product of plants and have considerable nutritional importance
in the human diet. The consumption of fruits is among the dietary strategies recommended …

Background Functional constipation (FC) is a common bowel disorder that prevails
worldwide. In China, although a heterogeneous prevalence of constipation is expected, it is …