Physical forces are ubiquitous in biological processes across scales and diverse contexts.
This review highlights the significance of mechanical forces in nervous system development …

Integrins are vital surface adhesion receptors that mediate interactions between the
extracellular matrix (ECM) and cells and are essential for cell migration and the …

Alteration of tissue mechanical properties is a physical hallmark of solid tumors including
gliomas. How tumor cells sense and regulate tissue mechanics is largely unknown. Here …

Dendritic cell (DC) vaccine was among the first FDA-approved cancer immunotherapies, but
has been limited by the modest cytotoxic T lymphocyte (CTL) response and therapeutic …

Durotaxis is a type of directed cell migration in which cells respond to a gradient of
extracellular stiffness. Using automated tracking of positional data for large sample sizes of …

Gliomas are a diverse group of primary central nervous system tumors that affect both
children and adults. Recent studies have revealed a dynamic cross talk that occurs between …

The extracellular matrix (ECM) is a salient feature of all solid tissues within the body. This
complex, acellular entity is composed of hundreds of individual molecules whose assembly …

Glioblastoma (GBM) is the most aggressive and common form of primary brain cancer.
Several decades of research have provided great insight into GBM progression; however …

It is widely accepted that three-dimensional cell culture systems simulate physiological
conditions better than traditional 2D systems. Although extracellular matrix components …

The invasion properties of glioblastoma hamper a radical surgery and are responsible for its
recurrence. Understanding the invasion mechanisms is thus critical to devise new …