Human temperature regulation under heat stress in health, disease, and injury

MN Cramer, D Gagnon, O Laitano… - Physiological …, 2022 - journals.physiology.org
1.1. Background During exercise and with exposure to hot climatic conditions, there is
tendency for the human body to store heat and for body temperatures to rise. Changes in …

The investigation of acute optic neuritis: a review and proposed protocol

A Petzold, MP Wattjes, F Costello… - Nature Reviews …, 2014 - nature.com
Optic neuritis is an inflammatory optic neuropathy that affects many patients with multiple
sclerosis (MS) at some point during their disease course. Differentiation of acute episodes of …

Smouldering multiple sclerosis: the 'real MS'

G Giovannoni, V Popescu, J Wuerfel… - Therapeutic …, 2022 - journals.sagepub.com
Using a philosophical approach or deductive reasoning, we challenge the dominant clinico-
radiological worldview that defines multiple sclerosis (MS) as a focal inflammatory disease …

Immunology of relapse and remission in multiple sclerosis

L Steinman - Annual review of immunology, 2014 - annualreviews.org
Eighty percent of individuals with multiple sclerosis (MS) initially develop a clinical pattern
with periodic relapses followed by remissions, called relapsing-remitting MS (RRMS). This …

The topographical model of multiple sclerosis: a dynamic visualization of disease course

SC Krieger, K Cook, S De Nino… - Neurology …, 2016 - AAN Enterprises
Relapses and progression contribute to multiple sclerosis (MS) disease course, but neither
the relationship between them nor the spectrum of clinical heterogeneity has been fully …

Diagnosis and classification of optic neuritis

A Petzold, CL Fraser, M Abegg, R Alroughani… - The Lancet …, 2022 - thelancet.com
There is no consensus regarding the classification of optic neuritis, and precise diagnostic
criteria are not available. This reality means that the diagnosis of disorders that have optic …

Temperature sensitivity in multiple sclerosis: an overview of its impact on sensory and cognitive symptoms

A Christogianni, R Bibb, SL Davis, O Jay, M Barnett… - Temperature, 2018 - Taylor & Francis
Multiple sclerosis (MS) is an autoimmune neurodegenerative disease characterized by
demyelination of the central nervous system (CNS). The exact cause of MS is still unknown; …

A new role for evoked potentials in MS? Repurposing evoked potentials as biomarkers for clinical trials in MS

M Hardmeier, L Leocani, P Fuhr - Multiple Sclerosis Journal, 2017 - journals.sagepub.com
Evoked potentials (EP) characterize signal conduction in selected tracts of the central
nervous system in a quantifiable way. Since alteration of signal conduction is the main …

The pathophysiology of motor fatigue and fatigability in multiple sclerosis

R Patejdl, UK Zettl - Frontiers in Neurology, 2022 - frontiersin.org
Multiple Sclerosis (MS) is a heterogeneous immune mediated disease of the central nervous
system (CNS). Fatigue is one of the most common and disabling symptom of MS. It interferes …

Management of multiple sclerosis relapses

P Repovic - CONTINUUM: Lifelong Learning in Neurology, 2019 - journals.lww.com
Management of Multiple Sclerosis Relapses : CONTINUUM: Lifelong Learning in Neurology
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