The neurotrophin brain-derived neurotrophic factor (BDNF) has emerged as a major
regulator of activity-dependent plasticity at excitatory synapses in the mammalian central …

Cardiac remodelling is classified as physiological (in response to growth, exercise and
pregnancy) or pathological (in response to inflammation, ischaemia, ischaemia/reperfusion …

Microglia maintain homeostasis in the brain. However, with age, they become primed and
respond more strongly to inflammatory stimuli. We show here that microglia from aged mice …

The mitogen-activated protein kinase (MAPK) interacting protein kinases 1 and 2 (Mnk1 and
Mnk2) play important roles in controlling signals involved in mRNA translation. In addition to …

Cellular stress is an intrinsic part of cell physiology that underlines cell survival or death. The
ability of mammalian cells to regulate global protein synthesis (aka translational control) …

Fasting is associated with a range of health benefits,,,,–. How fasting signals elicit changes
in the proteome to establish metabolic programmes remains poorly understood. Here we …

The central role of eukaryotic translation initiation factor 4E (eIF4E) in controlling mRNA
translation has been clearly assessed in the last decades. eIF4E function is essential for …

BDNF signaling contributes to protein-synthesis-dependent synaptic plasticity, but the
dynamics of TrkB signaling and mechanisms of translation have not been defined. Here, we …

As obligate parasites, viruses strictly depend on host cell translation for the production of
new progeny, yet infected cells also synthesize antiviral proteins to limit virus infection …

The MAP kinase signal-integrating kinases or MAP kinase-interacting protein kinases
(Mnks) are activated by signaling through the oncogenic MAP kinase (ERK) pathway. The …