Aldehyde dehydrogenase 2 (ALDH2) is an enzyme found in the mitochondrial matrix that
plays a central role in alcohol and aldehyde metabolism. A common ALDH2 polymorphism …

Reduced bioavailability of the nitric oxide (NO) signaling molecule has been associated with
the onset of cardiovascular disease. One of the better-known and effective therapies for …

Epilepsy is a complex and multifactorial neurodegenerative disease described by recurrent
seizures. Oxidative stress and dysregulation of brain-derived neurotrophic factor (BDNF) …

Myocardial infarction (MI) is the leading cause of death worldwide, and oxidative stress is
part of the process that causes MI. Calycosin, a naturally occurring substance with …

Background Aldehyde dehydrogenase‐2 (ALDH2), a mitochondrial enzyme, detoxifies
reactive aldehydes such as 4‐hydroxy‐2‐nonenal (4HNE). A highly prevalent E487K …

Aldehyde dehydrogenase 2 (ALDH2) detoxifies acetaldehyde produced from ethanol. A
missense single nucleotide polymorphism (SNP) rs671 in ALDH2 exhibits a dominant …

Regular exercise has many health benefits, among which is a significant reduction of
cardiovascular risk. Although many beneficial effects of exercise are well described, the …

To ameliorate diabetes mellitus-associated heart failure with preserved ejection fraction
(HFpEF), we plan to lower diabetes-mediated oxidative stress-induced 4-hydroxy-2-nonenal …

Background: We aimed to explore the role of mitochondrial aldehyde dehydrogenase 2
(ALDH2) in prostate cancer (PCa) patients and provide insights into the tumor immune …

Cancer is a major global health issue. Effective therapeutic strategies can prolong patients'
survival and reduce the costs of treatment. Drug repurposing, which identifies new …