Low bone mass and strength lead to fragility fractures, for example, in elderly individuals
affected by osteoporosis or children with osteogenesis imperfecta. A decade ago, rare …

The canonical Wnt/β-catenin signaling plays a fundamental role in regulating embryonic
development, injury repair and the pathogenesis of human diseases. In vertebrates, low …

R-spondin proteins strongly potentiate Wnt signalling and function as stem-cell growth
factors. Despite the biological and therapeutic significance, the molecular mechanism of R …

The adult stem cell marker Lgr5 and its relative Lgr4 are often co-expressed in Wnt-driven
proliferative compartments. We find that conditional deletion of both genes in the mouse gut …

Signaling by the Wnt family of secreted glycoproteins plays important roles in embryonic
development and adult homeostasis. Wnt signaling is modulated by a number of …

The transforming growth factor-β (TGF-β) signalling pathway is a key mediator of fibroblast
activation that drives the aberrant synthesis of extracellular matrix in fibrotic diseases. Here …

The Wnt/β-catenin signaling system plays essential roles in embryonic development and in
the self-renewal and maintenance of adult stem cells. R-spondins (RSPOs) are a group of …

The concept of a matricellular protein was first proposed by Paul Bornstein in the mid-1990s
to account for the non-lethal phenotypes of mice with inactivated genes encoding …

Signaling by the Wnt family of secreted glycolipoproteins via the transcriptional coactivator β-
catenin controls embryonic development and adult homeostasis. Here we review recent …

A remarkable interdisciplinary effort has unraveled the WNT (Wingless and INT-1) signal
transduction cascade over the last two decades. Wnt genes encode small secreted proteins …