Background Polypharmacy, the concomitant use of 5 or more medications, is highly
prevalent among older adults and individuals with multimorbid conditions and has been …

Background Frailty and adverse drug effects are linked in the fact that polypharmacy is
correlated with the severity of frailty; however, a causal relation has not been proven in older …

Background It is not known whether drugs with different anticholinergic ratings contribute
proportionately to overall anticholinergic score. Objectives Our objective was to assess the …

Objectives To examine the association between CNS medication burden and serious falls in
those with a recent fall history. Design Nested‐case control study; cases matched to four …

Background: Although it is generally accepted that anticholinergic use may lead to a fall,
results from studies assessing the association between anticholinergic use and falls are …

Despite their anticholinergic side effects, first-generation antihistamines are widely
prescribed to elderly patients. A systematic review was conducted to synthesize real-world …

Purpose In recent decades, the life expectancy of HIV-infected patients has increased
considerably, to the extent that the disease can now be considered chronic. In this context of …

Introduction Nonmedical opioid use (NMOU) in patients with cancer is a term covering a
spectrum of nonprescribed opioid use. The extent to which an individual uses opioids in a …

Although people with HIV infection (PLWH) are at higher risk of polypharmacy and
substance use, there is limited knowledge about potential harms associated with …

Abstract Purpose Higher Fit fOR The Aged (FORTA) scores have been shown to be
negatively associated with adverse clinical outcomes in older hospitalized patients. This has …