Glutamine, the most abundant free amino acid in the human body, is a major substrate
utilized by intestinal cells. The roles of glutamine in intestinal physiology and management …

Airway epithelium contributes significantly to the barrier function of airway tract. Mucociliary
escalator, intercellular apical junctional complexes which regulate paracellular permeability …

Steady-state turnover is a hallmark of epithelial tissues throughout adult life. Intestinal
epithelial turnover is marked by continuous cell migration, which is assumed to be driven by …

Programmed cell death (PCD) plays a key role in developmental biology and in
maintenance of the steady state in continuously renewing tissues. Currently, its existence is …

The gut is an obvious target for the development of functional foods, acting as it does as the
interface between diet and the metabolic events which sustain life. The key processes in …

The lining of the intestine is renewed at an extraordinary rate, outpacing all other tissues in
the vertebrate body. The renewal process is neatly organized in space, so that the whole …

The pancreas is an organ containing two distinct populations of cells, the exocrine cells that
secrete enzymes into the digestive tract, and the endocrine cells that secrete hormones into …

Studying the cross talk between nonpathogenic organisms and their mammalian hosts
represents an experimental challenge because these interactions are typically subtle and …

The regulation of cell number in adult tissues is determined by the balance of cell production
and cell loss. In the gastrointestinal tract, where there are well defined zones of proliferation …

Intestinal stem cells (ISCs) and colorectal cancer (CRC) biology are tightly linked in many
aspects. It is generally thought that ISCs are the cells of origin for a large proportion of CRCs …