DEHP: Genotoxicity and potential carcinogenic mechanisms—A review

JC Caldwell - Mutation Research/Reviews in Mutation Research, 2012 - Elsevier
Di (ethylhexyl) phthalate (DEHP) is a manufactured chemical commonly added to plastics: it
is a ubiquitous environmental contaminant to which humans are exposed through multiple …

Physiological functions of peroxisome proliferator-activated receptor β

JG Neels, PA Grimaldi - Physiological reviews, 2014 - journals.physiology.org
The peroxisome proliferator-activated receptors, PPARα, PPARβ, and PPARγ, are a family of
transcription factors activated by a diversity of molecules including fatty acids and fatty acid …

[HTML][HTML] Thematic review series: skin lipids. Peroxisome proliferator-activated receptors and liver X receptors in epidermal biology

M Schmuth, YJ Jiang, S Dubrac, PM Elias… - Journal of lipid …, 2008 - ASBMB
The epidermis is a very active site of lipid metabolism, and all peroxisome proliferator-
activated receptor (PPAR) and liver X receptor (LXR) isoforms are expressed in the …

Mechanistic considerations for human relevance of cancer hazard of di (2-ethylhexyl) phthalate

I Rusyn, JC Corton - Mutation Research/Reviews in Mutation Research, 2012 - Elsevier
Di (2-ethylhexyl) phthalate (DEHP) is a peroxisome proliferator agent that is widely used as
a plasticizer to soften polyvinylchloride plastics and non-polymers. Both occupational (eg, by …

Role of peroxisome-proliferator-activated receptor β/δ (PPARβ/δ) in gastrointestinal tract function and disease

JM Peters, HE Hollingshead, FJ Gonzalez - Clinical science, 2008 - portlandpress.com
PPARβ/δ (peroxisome-proliferator-activated receptor β/δ) is one of three PPARs in the
nuclear hormone receptor superfamily that are collectively involved in the control of lipid …

[PDF][PDF] Peroxisome proliferator‐activated receptor‐β/δ protects against chemically induced liver toxicity in mice

W Shan, CJ Nicol, S Ito, MT Bility, MJ Kennett… - …, 2008 - Wiley Online Library
Potential functional roles for the peroxisome proliferator‐activated receptor‐β/δ (PPARβ/δ) in
skeletal muscle fatty acid catabolism and epithelial carcinogenesis have recently been …

Sorting out the functional role (s) of peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) in cell proliferation and cancer

JM Peters, FJ Gonzalez - Biochimica et Biophysica Acta (BBA)-Reviews on …, 2009 - Elsevier
Peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) has many beneficial physiological
functions ranging from enhancing fatty acid catabolism, improving insulin sensitivity …

Ligand activation of peroxisome proliferator–activated receptor β/δ (PPARβ/δ) attenuates carbon tetrachloride hepatotoxicity by downregulating proinflammatory gene …

W Shan, PS Palkar, IA Murray, EI McDevitt… - Toxicological …, 2008 - academic.oup.com
Peroxisome proliferator–activated receptor (PPAR) β/δ–null mice exhibit exacerbated
hepatotoxicity in response to administration of carbon tetrachloride (CCl4). To determine …

Di-(2-ethylhexyl) phthalate aggravates psoriasis-like skin lesions: In vitro and in vivo evaluation

Y Qian, L Zhu, J Chen, Y Zhou, Z Huang, L Liang… - Toxicology and Applied …, 2023 - Elsevier
Abstract Di-(2-ethylhexyl) phthalate (DEHP), which is a widely used phthalate (PAE), has
recently received public attention owing to it causing health problems. The aim of this study …

Peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) ligands inhibit growth of UACC903 and MCF7 human cancer cell lines

EE Girroir, HE Hollingshead, AN Billin, TM Willson… - Toxicology, 2008 - Elsevier
The development of peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) ligands for the
treatment of diseases including metabolic syndrome, diabetes and obesity has been …