Abstract Glutathione peroxidase 4 (GPx4) moonlights as structural protein and antioxidase
that powerfully inhibits lipid oxidation. In the past years, it is considered as a key regulator of …

Ferroptosis (FPT) is a form of cell death due to missed control of membrane lipid
peroxidation (LPO). According to the axiomatic definition of non-accidental cell death, LPO …

Significance: The selenium-containing Glutathione peroxidases (GPxs) 1–4 protect against
oxidative challenge, inhibit inflammation and oxidant-induced regulated cell death. Recent …

Despite the development of novel targeted drugs, the molecular heterogeneity of diffuse
large B-cell lymphoma (DLBCL) still poses a substantial therapeutic challenge. DLBCL can …

Motivation: Promoter analysis is an essential step on the way to identify regulatory networks.
A prerequisite for successful promoter analysis is the prediction of potential transcription …

The purification of a protein inhibiting lipid peroxidation led to the discovery of the
selenoperoxidase GPx4 forty years ago. Thus, the evidence of the enzymatic activity was …

Abstract Glutathione peroxidase 4 (GP x4) is the only enzyme capable of reducing toxic lipid
hydroperoxides in biological membranes to the corresponding alcohols using glutathione as …

Abstract Analysis of the selenoproteome identified five glutathione peroxidases (GPxs) in
mammals: cytosolic GPx (cGPx, GPx1), phospholipid hydroperoxide GPx (PHGPX, GPx4) …

The gastrointestinal glutathione peroxidase (GI-GPx, GPx2) is a selenoprotein that was
suggested to act as barrier against hydroperoxide absorption but has also been implicated …

Ferroptosis, characterized by excessive iron accumulation and lipid peroxidation, is a novel
form of iron-dependent cell death, which is morphologically, genetically, and biochemically …