Cryptococcus spp., in particular Cryptococcus neoformans and Cryptococcus gattii, have an
enormous impact on human health worldwide. The global burden of cryptococcal meningitis …

Highlights•Our limited arsenal of antifungals is threatened by drug-resistant fungal
pathogens.•Inherent resistance is when all strains of a species show antifungal …

The high rates of morbidity and mortality caused by fungal infections are associated with the
current limited antifungal arsenal and the high toxicity of the compounds. Additionally …

Background Emerging fungal pathogens pose important threats to global public health. The
World Health Organization has responded to the rising threat of traditionally neglected …

Fungal infections, such as candidiasis caused by Candida, pose a problem of growing
medical concern. In developed countries, the incidence of Candida infections is increasing …

Rezafungin (formerly CD101) is a new β-glucan synthase inhibitor that is chemically related
with anidulafungin. It is considered the first molecule of the new generation of long-acting …

Treatment modalities for systemic mycoses are still limited. Currently, the main antifungal
therapeutics include polyenes, azoles, and echinocandins. However, even in the setting of …

Besides inherent differences in in vitro susceptibilities, clinically-relevant yeast species may
acquire resistance upon exposure to most antifungal drugs used in the clinic. In recent …

Due to the limit of available treatments and the emergence of drug resistance in the clinic,
invasive fungal infections are an intractable problem with high morbidity and mortality. The …

Biomembranes constitute the first lines of defense of cells. While small molecules can often
permeate cell walls in bacteria and plants, they are generally unable to penetrate the barrier …