The regulation and functions of DNA and RNA G-quadruplexes

D Varshney, J Spiegel, K Zyner, D Tannahill… - … reviews Molecular cell …, 2020 - nature.com
DNA and RNA can adopt various secondary structures. Four-stranded G-quadruplex (G4)
structures form through self-recognition of guanines into stacked tetrads, and considerable …

Shaping human telomeres: from shelterin and CST complexes to telomeric chromatin organization

CJ Lim, TR Cech - Nature Reviews Molecular Cell Biology, 2021 - nature.com
The regulation of telomere length in mammals is crucial for chromosome end-capping and
thus for maintaining genome stability and cellular lifespan. This process requires …

Aggregation-induced emission: together we shine, united we soar!

J Mei, NLC Leung, RTK Kwok, JWY Lam… - Chemical …, 2015 - ACS Publications
Light is of essential importance to the universe and humankind. Light has been, and
continues to be, one of the most fundamental and indispensable elements to life and society …

The MRE11–RAD50–NBS1 complex conducts the orchestration of damage signaling and outcomes to stress in DNA replication and repair

A Syed, JA Tainer - Annual review of biochemistry, 2018 - annualreviews.org
Genomic instability in disease and its fidelity in health depend on the DNA damage
response (DDR), regulated in part from the complex of meiotic recombination 11 homolog 1 …

DNA quadruple helices in nanotechnology

JL Mergny, D Sen - Chemical Reviews, 2019 - ACS Publications
DNA has played an early and powerful role in the development of bottom-up
nanotechnologies, not least because of DNA's precise, predictable, and controllable …

G-quadruplexes: prediction, characterization, and biological application

CK Kwok, CJ Merrick - Trends in biotechnology, 2017 - cell.com
Guanine (G)-rich sequences in nucleic acids can assemble into G-quadruplex structures that
involve G-quartets linked by loop nucleotides. The structural and topological diversity of G …

G-quadruplexes at telomeres: friend or foe?

TM Bryan - Molecules, 2020 - mdpi.com
Telomeres are DNA-protein complexes that cap and protect the ends of linear
chromosomes. In almost all species, telomeric DNA has a G/C strand bias, and the short …

RNA G-quadruplexes (rG4s): genomics and biological functions

K Lyu, EYC Chow, X Mou, TF Chan… - Nucleic acids …, 2021 - academic.oup.com
Abstract G-quadruplexes (G4s) are non-classical DNA or RNA secondary structures that
have been first observed decades ago. Over the years, these four-stranded structural motifs …

DNA secondary structures: stability and function of G-quadruplex structures

ML Bochman, K Paeschke, VA Zakian - Nature Reviews Genetics, 2012 - nature.com
In addition to the canonical double helix, DNA can fold into various other inter-and
intramolecular secondary structures. Although many such structures were long thought to be …

Properties and biological impact of RNA G-quadruplexes: from order to turmoil and back

P Kharel, G Becker, V Tsvetkov… - Nucleic acids research, 2020 - academic.oup.com
Abstract Guanine-quadruplexes (G4s) are non-canonical four-stranded structures that can
be formed in guanine (G) rich nucleic acid sequences. A great number of G-rich sequences …