Hox genes are an evolutionary highly conserved gene family. They determine the anterior-
posterior body axis in bilateral organisms and influence the developmental fate of cells …

Infant B-cell acute lymphoblastic leukemia (B-ALL) accounts for 10% of childhood ALL. The
genetic hallmark of most infant B-ALL is chromosomal rearrangements of the mixed-lineage …

B-cell acute lymphoblastic leukemia is the commonest childhood cancer. In infants, B-cell
acute lymphoblastic leukemia remains fatal, especially in patients with t (4; 11), present in …

Chromosome translocations involving the mixed lineage leukemia (MLL) gene fuse it in
frame with multiple partner genes creating novel fusion proteins (MLL-FPs) that cause …

Summary The t (4; 11)(q21; q23) fuses mixed-lineage leukemia (MLL) to AF4, the most
common MLL-fusion partner. Here we show that MLL fused to murine Af4, highly conserved …

B cell leukaemia is one of the most frequent malignancies in the paediatric population, but
also affects a significant proportion of adults in developed countries. The majority of infant …

The molecular determinants regulating the specification of human embryonic stem cells
(hESCs) into hematopoietic cells remain elusive. HOXA9 plays a relevant role in …

Increasing evidence supports that mesenchymal stromal/stem cells (MSCs) may represent
the target cell for sarcoma development. Although different sarcomas have been modeled in …

Human induced pluripotent stem cells (hiPSC) have been generated from different tissues,
with the age of the donor, tissue source and specific cell type influencing the reprogramming …

MLL rearrangements play a crucial role in leukemogenesis and comprise a poor prognosis.
Therefore, new treatment strategies are urgently needed. We used the CRISPR/Cas9 …