There has been a resurgence in the clinical use of polymyxin antibiotics such as colistin due
to the limited treatment options for infections caused by carbapenem-resistant …

With the rising incidences of antimicrobial resistance (AMR) and the diminishing options of
novel antimicrobial agents, it is paramount to decipher the molecular mechanisms of action …

Colonization of the gastrointestinal (GI) tract by Klebsiella pneumoniae is generally
considered asymptomatic. However, gut colonization allows K. pneumoniae to either …

Concerns about colistin-resistant bacteria in animal food-environmental-human ecosystems
prompted the poultry sector to implement colistin restrictions and explore alternative trace …

Background Colistin has emerged as a last-resort therapeutic against antibiotic-resistant
bacterial infections, particularly those attributed to carbapenem-resistant Enterobacteriaceae …

Successful microbial colonization of the gastrointestinal (GI) tract hinges on an organism's
ability to overcome the intense competition for nutrients in the gut between the host and the …

The cost of resistance Page 1 in brief 0123456789();: nature reviews | Microbiology
MICROBIOME Mobilizing resistance genes in the human gut Antibiotic resistance genes (ARGs) …

Background Colistin is used as a last resort for managing infections caused by multidrug-
resistant bacteria. However, the high emergence of colistin-resistant strains has restricted …

Bacterial infections pose a significant global health threat, accounting for an estimated 7.7
million deaths. Hospital outbreaks driven by multi-drug-resistant pathogens, notably …

The archetypal PhoQP two-component system from Enterobacteria regulates pathways like
magnesium homeostasis in Escherichia coli and virulence factor expression in Salmonella …