Inflammatory bowel diseases (IBDs) are chronic immune-mediated conditions characterized
by significant gut tissue damage due to uncontrolled inflammation. Anti-inflammatory …

Mitochondria are key cellular organelles whose main function is maintaining cell
bioenergetics by producing ATP through oxidative phosphorylation. However, mitochondria …

Background Leucine‐rich repeat kinase 2 (LRRK2) is a common risk gene for Parkinson's
disease (PD) and inflammatory bowel disorders. However, the penetrance of the most …

The heterogeneous pathobiology underlying Ulcerative Colitis (UC) is not fully understood.
Using publicly available transcriptomes from adult UC patients, we identified the immune …

Endurance exercise has a dramatic impact on the functionality of mitochondria and on the
composition of the intestinal microbiome, but the mechanisms regulating the crosstalk …

In addition to their classical roles as bacterial sensors, NOD1 and NOD2 have been
implicated as mediators of metabolic disease. Increased expression of NOD1 and/or NOD2 …

Background Long noncoding RNA (lncRNA) is receiving growing attention in Crohn's
disease (CD). However, the mechanism by which herb-partitioned moxibustion (HPM) …

Background: The cause of ulcerative colitis (UC) is not yet fully understood. Previous
research has pointed towards a potential role for mutations in nucleotide-binding …

IF1 is a mitochondrial protein involved in the regulation of ATP synthase activity. The role of
IF1 remains to be established in inflammatory bowel diseases (IBD). In this study, we report …

Sleep disorders are progressively common and sometimes are associated with aberrant
regulation of the adaptive and innate immune responses. Sleep interruption can increase …