Acid-sensing ion channels (ASICs) are voltage-independent H+-gated cation channels
largely expressed in the nervous system of rodents and humans. At least six isoforms …

Osteoarthritis (OA) is a highly prevalent joint disease that causes substantial disability, yet
effective approaches to disease prevention or to the delay of OA progression are lacking …

Sensing acidosis is an important somatosensory function in responses to ischemia,
inflammation, and metabolic alteration. Accumulating evidence has shown that acidosis is …

Introduction The accelerated aging of the global population has emerged as a critical public
health concern, with increasing recognition of the influential role played by the microbiome …

Psoriasis is an immune-mediated skin disease associated with neurogenic inflammation, but
the underlying molecular mechanism remains unclear. We demonstrate here that acid …

Lysophosphatidyl-choline (LPC), a member of the phospholipid family, is an emerging
player in pain. It is known to modulate different pain-related ion channels, including Acid …

Lysophosphatidic acid (LPA) is a phospholipid which has been implicated in pain. Acid‐
sensing ion channels (ASICs) are important players in pain associated with tissue …

Synovial fluid (SF) from human knee joints with osteoarthritis (OA) has elevated levels of
lysophosphatidylcholine (LPC) species, but their functional role is not well understood. This …

Lipid-rich diet is the major cause of obesity, affecting 13% of the worldwide adult population.
Obesity is a major risk factor for metabolic syndrome that includes hyperlipidemia and …

The bioactive lipid lysophosphatidylcholine (LPC), a major phospholipid component of
oxidized low-density lipoprotein (Ox-LDL), originates from the cleavage of …