Mechanisms of action of the peptide toxins targeting human and rodent acid-sensing ion channels and relevance to their in vivo analgesic effects

C Verkest, M Salinas, S Diochot, E Deval, E Lingueglia… - Toxins, 2022 - mdpi.com
Acid-sensing ion channels (ASICs) are voltage-independent H+-gated cation channels
largely expressed in the nervous system of rodents and humans. At least six isoforms …

Ion channels in osteoarthritis: emerging roles and potential targets

R Zhou, W Fu, D Vasylyev, SG Waxman… - Nature Reviews …, 2024 - nature.com
Osteoarthritis (OA) is a highly prevalent joint disease that causes substantial disability, yet
effective approaches to disease prevention or to the delay of OA progression are lacking …

Acidosis-related pain and its receptors as targets for chronic pain

CH Hung, Y Chin, YO Fong, CH Lee, DS Han… - Pharmacology & …, 2023 - Elsevier
Sensing acidosis is an important somatosensory function in responses to ischemia,
inflammation, and metabolic alteration. Accumulating evidence has shown that acidosis is …

Multi-omics analysis reveals substantial linkages between the oral-gut microbiomes and inflamm-aging molecules in elderly pigs

C Qiao, M He, S Wang, X Jiang, F Wang, X Li… - Frontiers in …, 2023 - frontiersin.org
Introduction The accelerated aging of the global population has emerged as a critical public
health concern, with increasing recognition of the influential role played by the microbiome …

Sensory ASIC3 channel exacerbates psoriatic inflammation via a neurogenic pathway in female mice

C Huang, PY Sun, Y Jiang, Y Liu, Z Liu, SL Han… - Nature …, 2024 - nature.com
Psoriasis is an immune-mediated skin disease associated with neurogenic inflammation, but
the underlying molecular mechanism remains unclear. We demonstrate here that acid …

Single subcutaneous injection of lysophosphatidyl-choline evokes ASIC3-dependent increases of spinal dorsal horn neuron activity

L Pidoux, K Delanoe, J Barbier, F Marchand… - Frontiers in Molecular …, 2022 - frontiersin.org
Lysophosphatidyl-choline (LPC), a member of the phospholipid family, is an emerging
player in pain. It is known to modulate different pain-related ion channels, including Acid …

Potentiation of ASIC currents by lysophosphatidic acid in rat dorsal root ganglion neurons

Q Li, WL Qiao, JW Hao, S Wei, XM Li… - Journal of …, 2022 - Wiley Online Library
Lysophosphatidic acid (LPA) is a phospholipid which has been implicated in pain. Acid‐
sensing ion channels (ASICs) are important players in pain associated with tissue …

Functional Characterization of Lysophospholipids by Proteomic and Lipidomic Analysis of Fibroblast-like Synoviocytes

T Timm, C Hild, G Liebisch, M Rickert, G Lochnit… - Cells, 2023 - mdpi.com
Synovial fluid (SF) from human knee joints with osteoarthritis (OA) has elevated levels of
lysophosphatidylcholine (LPC) species, but their functional role is not well understood. This …

Acid-sensing ion channel 3 mediates pain hypersensitivity associated with high-fat diet consumption in mice

A Negm, K Stobbe, SB Fradj, C Sanchez… - Pain, 2024 - journals.lww.com
Lipid-rich diet is the major cause of obesity, affecting 13% of the worldwide adult population.
Obesity is a major risk factor for metabolic syndrome that includes hyperlipidemia and …

Lysophosphatidylcholine: Potential target for the treatment of chronic pain

J Ren, J Lin, L Yu, M Yan - International Journal of Molecular Sciences, 2022 - mdpi.com
The bioactive lipid lysophosphatidylcholine (LPC), a major phospholipid component of
oxidized low-density lipoprotein (Ox-LDL), originates from the cleavage of …