Mechanism and applications of CRISPR/Cas-9-mediated genome editing
M Asmamaw, B Zawdie - Biologics: targets and therapy, 2021 - Taylor & Francis
Clustered regularly interspaced short palindromic repeat (CRISPR) and their associated
protein (Cas-9) is the most effective, efficient, and accurate method of genome editing tool in …
protein (Cas-9) is the most effective, efficient, and accurate method of genome editing tool in …
Evolutionary classification of CRISPR–Cas systems: a burst of class 2 and derived variants
The number and diversity of known CRISPR–Cas systems have substantially increased in
recent years. Here, we provide an updated evolutionary classification of CRISPR–Cas …
recent years. Here, we provide an updated evolutionary classification of CRISPR–Cas …
Innovation can accelerate the transition towards a sustainable food system
Future technologies and systemic innovation are critical for the profound transformation the
food system needs. These innovations range from food production, land use and emissions …
food system needs. These innovations range from food production, land use and emissions …
[HTML][HTML] Strategies to overcome the main challenges of the use of CRISPR/Cas9 as a replacement for cancer therapy
CRISPR/Cas9 (clustered regularly interspaced short palindromic repeats-associated protein
9) shows the opportunity to treat a diverse array of untreated various genetic and …
9) shows the opportunity to treat a diverse array of untreated various genetic and …
Synthetic lethality as an engine for cancer drug target discovery
A Huang, LA Garraway, A Ashworth… - Nature reviews Drug …, 2020 - nature.com
The first wave of genetically targeted therapies for cancer focused on drugging gene
products that are recurrently mutated in specific cancer types. However, mutational analysis …
products that are recurrently mutated in specific cancer types. However, mutational analysis …
[HTML][HTML] Review of current COVID-19 diagnostics and opportunities for further development
Y Mardian, H Kosasih, M Karyana, A Neal… - Frontiers in …, 2021 - frontiersin.org
Diagnostic testing plays a critical role in addressing the coronavirus disease 2019 (COVID-
19) pandemic, caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV …
19) pandemic, caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV …
Deafness: from genetic architecture to gene therapy
Progress in deciphering the genetic architecture of human sensorineural hearing
impairment (SNHI) or loss, and multidisciplinary studies of mouse models, have led to the …
impairment (SNHI) or loss, and multidisciplinary studies of mouse models, have led to the …
Amplification‐free detection of SARS‐CoV‐2 and respiratory syncytial virus using CRISPR Cas13a and graphene field‐effect transistors
The clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR‐
associated (Cas) systems have recently received notable attention for their applications in …
associated (Cas) systems have recently received notable attention for their applications in …
[HTML][HTML] Various aspects of a gene editing system—crispr–cas9
E Janik, M Niemcewicz, M Ceremuga… - International journal of …, 2020 - mdpi.com
The discovery of clustered, regularly interspaced short palindromic repeats (CRISPR) and
their cooperation with CRISPR-associated (Cas) genes is one of the greatest advances of …
their cooperation with CRISPR-associated (Cas) genes is one of the greatest advances of …
CRISPR-based detection of SARS-CoV-2: A review from sample to result
The current pandemic of the 2019 novel coronavirus (COVID-19) caused by SARS-CoV-2
(severe acute respiratory syndrome coronavirus-2) has raised significant public health …
(severe acute respiratory syndrome coronavirus-2) has raised significant public health …