Neurodegenerative diseases have two general characteristics that are so fundamental we
usually take them for granted. The first is that the pathology associated with the disease only …

Intracellular α-synuclein (α-syn)-rich protein aggregates called Lewy pathology (LP) and
neuronal death are commonly found in the brains of patients with clinical Parkinson disease …

For the last two decades, pathogenic concepts in Parkinson disease (PD) have revolved
around the toxicity and spread of α-synuclein. Thus, α-synuclein would follow caudo-rostral …

Significant advances have been made uncovering the factors that render neurons
vulnerable in Parkinson's disease (PD). However, the critical pathogenic events leading to …

A relatively small number of especially susceptible nerve cell types within multiple
neurotransmitter systems of the human central, peripheral, and enteric nervous systems …

Dopamine metabolism, alpha-synuclein pathology, and iron homeostasis have all been
implicated as potential contributors to the unique vulnerability of substantia nigra …

Many aspects of cognition and behaviour are regulated by noradrenergic projections to the
forebrain originating from the locus coeruleus, acting through alpha and beta …

Genome-wide association studies have discovered hundreds of loci associated with
complex brain disorders, but it remains unclear in which cell types these loci are active. Here …

Background Parkinson's disease (PD) is a progressive neurodegenerative disorder
associated with a loss of dopaminergic (DA) neurons. Despite symptomatic therapies, there …

Parkinson's disease (PD) is the second most common progressive neurodegenerative
disorder mainly in middle‐elderly population, which represents diverse nonmotor symptoms …