Osteoarthritis comprises several joint disorders characterized by articular cartilage
degeneration and persistent pain, causing disability and economic burden. The incidence of …

Originally isolated from bone marrow, mesenchymal stromal cells (MSCs) have since been
obtained from various fetal and post-natal tissues and are the focus of an increasing number …

Osteogenesis during bone modeling and remodeling is coupled with angiogenesis. A recent
study showed that a specific vessel subtype, strongly positive for CD31 and endomucin …

Articular cartilage repair and regeneration provides a substantial challenge in Regenerative
Medicine because of the high degree of morphological and mechanical complexity intrinsic …

Traditional vascular grafts constructed from synthetic polymers or cadaveric human or
animal tissues support the clinical need for readily available blood vessels, but often come …

Pericytes, the mural cells of blood microvessels, regulate microvascular development and
function and have been implicated in many brain diseases. However, due to a paucity of …

With the increasing global prevalence of diabetes mellitus, a significant rise in the number of
patients suffering from non-healing wounds is expected. However, available treatments …

Mesenchymal stem cells (MSCs) are self-renewable cells capable for multilineage
differentiation and immunomodulation. MSCs are able to differentiate into all cell types of …

Background Brain inflammation plays a key role in neurological disease. Although much
research has been conducted investigating inflammatory events in animal models, potential …

Biomaterials are playing an increased role in the regeneration of damaged or absent bone
tissue in the context of trauma, non-union, infection or congenital abnormality. Restoration of …