Melanoma is the most lethal skin cancer that originates from the malignant transformation of
melanocytes. Although melanoma has long been regarded as a cancerous malignancy with …

In less than 10 years, melanoma treatment has been revolutionized with the approval of
tyrosine kinase inhibitors and immune checkpoint inhibitors, which have been shown to …

Mitochondrial DNA (mtDNA) is a potent agonist of the innate immune system; however, the
exact immunostimulatory features of mtDNA and the kinetics of detection by cytosolic nucleic …

Wnt signaling is one of the key cascades regulating development and stemness, and has
also been tightly associated with cancer. The role of Wnt signaling in carcinogenesis has …

Immunotherapeutic interventions are showing effectiveness across a wide range of cancer
types, but only a subset of patients shows clinical response to therapy. Responsiveness to …

Over the past 25 years, research in cancer therapeutics has largely focused on two distinct
lines of enquiry. In one approach, efforts to understand the underlying cell-autonomous …

Wnt/β-catenin signaling is an evolutionarily conserved and versatile pathway that is known
to be involved in embryonic development, tissue homeostasis and a wide variety of human …

Large numbers of melanoma lesions develop resistance to targeted inhibition of mutant
BRAF or fail to respond to checkpoint blockade. We explored whether modulation of …

Wnt/β-catenin signaling, a highly conserved pathway through evolution, regulates key
cellular functions including proliferation, differentiation, migration, genetic stability …

Melanomas on sun-exposed skin are heterogeneous tumours, which can be subtyped on
the basis of their cumulative levels of exposure to ultraviolet (UV) radiation. A melanocytic …