Steroids constitute a unique class of chemical compounds, playing an important role in
physiopathological processes, and have high pharmacological interest. Additionally …

A series of novel 3β, 7α, 11α-trihydroxy-pregn-21-benzylidene-5-en-20-one derivatives were
synthesized and characterized by NMR, HRMS. The pregnenolone (1) was first …

As a part of our investigations into the structural–activity relationship studies of a novel class
of medicinally active 16-substituted steroids, several new 16-imidazolyl substituted steroidal …

Neuroinflammatory mechanisms mediated by activated glial and cytokines (TNF-α, IL-1β)
might contribute to neuronal degeneration leading to Alzheimer's (AD) and Parkinson's …

Switchable polarity recyclable solvent mixtures were applied as reaction medium and
catalyst to replace the conventional base catalysts in the Claisen–Schmidt condensation of …

Résumé In this study, synthesis, structural characterization, molecular docking studies, and
antiproliferative effects in four different cell lines of several novel 16-arylidene-4-azaandrost …

The synthesis and cytotoxic studies of a new series of 16E-arylidene androstene derivatives
are reported herein. The impact of incorporating bis-tertiary amino functionalities in the …

A series of new 16E-arylidene androstane derivatives were synthesized and characterized.
The new compounds were screened for their anticancer activities against the human cancer …

In order to determine the structural requirements for cytotoxicity against various tumor cell
lines, a new series of 16E-arylidene androstene amides with varying degrees of …

Taking into consideration the structural requirements for cytotoxicity and aromatase
inhibition, several new 16E-arylidenosteroidal derivatives have been prepared and …