Focus on desynchronization rather than excitability: a new strategy for intraencephalic electrical stimulation
D de Castro Medeiros, MFD Moraes - Epilepsy & Behavior, 2014 - Elsevier
Epilepsy is a severely debilitating brain disease, often associated with premature death,
which has an urgent need for alternative methods of treatment. In fact, roughly 25% of …
which has an urgent need for alternative methods of treatment. In fact, roughly 25% of …
[HTML][HTML] On temporal scale-free non-periodic stimulation and its mechanisms as an infinite improbability drive of the brain's functional connectogram
Rationalized development of electrical stimulation (ES) therapy is of paramount importance.
Not only it will foster new techniques and technologies with increased levels of safety …
Not only it will foster new techniques and technologies with increased levels of safety …
[HTML][HTML] Bistable firing pattern in a neural network model
Excessively high, neural synchronization has been associated with epileptic seizures, one of
the most common brain diseases worldwide. A better understanding of neural …
the most common brain diseases worldwide. A better understanding of neural …
Closed-loop seizure control with very high frequency electrical stimulation at seizure onset in the GAERS model of absence epilepsy
TS Nelson, CL Suhr, DR Freestone, A Lai… - … journal of neural …, 2011 - World Scientific
A closed-loop system for the automated detection and control of epileptic seizures was
created and tested in three Genetic Absence Epilepsy Rats from Strasbourg (GAERS) rats …
created and tested in three Genetic Absence Epilepsy Rats from Strasbourg (GAERS) rats …
[HTML][HTML] The endocannabinoid system activation as a neural network desynchronizing mediator for seizure suppression
The understanding that hyper-excitability and hyper-synchronism in epilepsy are
indissociably bound by a cause-consequence relation has only recently been challenged …
indissociably bound by a cause-consequence relation has only recently been challenged …
The epileptic amygdala: toward the development of a neural prosthesis by temporally coded electrical stimulation
VR Cota, BMB Drabowski… - Journal of …, 2016 - Wiley Online Library
Many patients with epilepsy do not obtain proper control of their seizures through
conventional treatment. We review aspects of the pathophysiology underlying epileptic …
conventional treatment. We review aspects of the pathophysiology underlying epileptic …
[HTML][HTML] Amygdala low-frequency stimulation reduces pathological phase-amplitude coupling in the pilocarpine model of epilepsy
Temporal-lobe epilepsy (TLE) is the most common type of drug-resistant epilepsy and
warrants the development of new therapies, such as deep-brain stimulation (DBS). DBS was …
warrants the development of new therapies, such as deep-brain stimulation (DBS). DBS was …
[HTML][HTML] Epilepsy as a dynamical system, a most needed paradigm shift in epileptology
The idea of the epileptic brain being highly excitable and facilitated to synchronic activity has
guided pharmacological treatment since the early twentieth century. Although tackling …
guided pharmacological treatment since the early twentieth century. Although tackling …
Rapid brief feedback intracerebral stimulation based on real‐time desynchronization detection preceding seizures stops the generation of convulsive paroxysms
Objective To investigate the abortion of seizure generation using “minimal” intervention in
hippocampi using two rat models of human temporal lobe epilepsy. Methods The recording …
hippocampi using two rat models of human temporal lobe epilepsy. Methods The recording …
SaBer DBS: a fully programmable, rechargeable, bilateral, charge-balanced preclinical microstimulator for long-term neural stimulation
To effectively study the mechanisms by which deep brain stimulation (DBS) produces its
therapeutic benefit and to evaluate new therapeutic indications, it is vital to administer DBS …
therapeutic benefit and to evaluate new therapeutic indications, it is vital to administer DBS …