Contribution of semen to early embryo development: fertilization and beyond
M Vallet-Buisan, R Mecca, C Jones… - Human …, 2023 - academic.oup.com
BACKGROUND It has long been thought that the factors affecting embryo and foetal
development were exclusively maternally derived; hence, if issues regarding fertility and …
development were exclusively maternally derived; hence, if issues regarding fertility and …
[HTML][HTML] Chromatin attachment to the nuclear matrix represses hypocotyl elongation in Arabidopsis thaliana
The nuclear matrix is a nuclear compartment that has diverse functions in chromatin
regulation and transcription. However, how this structure influences epigenetic modifications …
regulation and transcription. However, how this structure influences epigenetic modifications …
[HTML][HTML] Species-specific differences in sperm chromatin decondensation between eutherian mammals underlie distinct lysis requirements
J Ribas-Maynou, E Garcia-Bonavila… - Frontiers in Cell and …, 2021 - frontiersin.org
Sperm present a highly particular DNA condensation that is acquired during their
differentiation. Protamines are key elements for DNA condensation. However, whereas the …
differentiation. Protamines are key elements for DNA condensation. However, whereas the …
[HTML][HTML] Successful large gene augmentation of USH2A with non-viral episomal vectors
M Toms, L Toualbi, PV Almeida, R Harbottle… - Molecular Therapy, 2023 - cell.com
USH2A mutations are a common cause of autosomal recessive retinitis pigmentosa (RP)
and Usher syndrome, for which there are currently no approved treatments. Gene …
and Usher syndrome, for which there are currently no approved treatments. Gene …
Nuclear organization by satellite DNA, SAF-A/hnRNPU and matrix attachment regions
OI Podgornaya - Seminars in Cell & Developmental Biology, 2022 - Elsevier
The need of large-scale chromatin organization in the nucleus has become more and more
appreciated. The higher order nuclear organization ultimately regulate a plethora of …
appreciated. The higher order nuclear organization ultimately regulate a plethora of …
Quantification of epigenetic DNA modifications in the subchromatin structure matrix attachment regions by stable isotope dilution UHPLC-MS/MS analysis
R Zhang, W Lai, H Wang - Analytical Chemistry, 2021 - ACS Publications
To date, subchromatin structure-based quantification of epigenetic DNA modifications is
limited. Matrix attachment regions (MARs), an important subchromatin structure, contain …
limited. Matrix attachment regions (MARs), an important subchromatin structure, contain …
[HTML][HTML] Polymer Modeling Reveals Interplay between Physical Properties of Chromosomal DNA and the Size and Distribution of Condensin-Based Chromatin Loops
Transient DNA loops occur throughout the genome due to thermal fluctuations of DNA and
the function of SMC complex proteins such as condensin and cohesin. Transient …
the function of SMC complex proteins such as condensin and cohesin. Transient …
HOXA9 forms a repressive complex with nuclear matrix–associated protein SAFB to maintain acute myeloid leukemia
S Agrawal-Singh, J Bagri, G Giotopoulos, DMA Azazi… - Blood, 2023 - ashpublications.org
HOXA9 is commonly upregulated in acute myeloid leukemia (AML), in which it confers a
poor prognosis. Characterizing the protein interactome of endogenous HOXA9 in human …
poor prognosis. Characterizing the protein interactome of endogenous HOXA9 in human …
The twisted path of the 3D genome: where does it lead?
SV Razin, OL Kantidze - Trends in Biochemical Sciences, 2022 - cell.com
A new era in 3D genome studies began with the development of the so-called 'C-methods',
used for the analysis of spatial contacts between distant genomic elements. However, the …
used for the analysis of spatial contacts between distant genomic elements. However, the …