A clinical approach to diagnosis of autoimmune encephalitis

F Graus, MJ Titulaer, R Balu, S Benseler… - The lancet …, 2016 - thelancet.com
Encephalitis is a severe inflammatory disorder of the brain with many possible causes and a
complex differential diagnosis. Advances in autoimmune encephalitis research in the past …

LGI1, CASPR2 and related antibodies: a molecular evolution of the phenotypes

SNM Binks, CJ Klein, P Waters, SJ Pittock… - Journal of Neurology …, 2018 - jnnp.bmj.com
Recent biochemical observations have helped redefine antigenic components within the
voltage-gated potassium channel (VGKC) complex. The related autoantibodies may be now …

The clinical spectrum of Caspr2 antibody–associated disease

A van Sonderen, H Ariño, M Petit-Pedrol, F Leypoldt… - Neurology, 2016 - AAN Enterprises
Objective: To report a large cohort of patients with antibodies against contactin-associated
protein-like 2 (Caspr2) and provide the clinical spectrum of this disorder. Methods: Serum …

Expanded phenotypes and outcomes among 256 LGI 1/CASPR 2‐I g G–positive patients

A Gadoth, SJ Pittock, D Dubey, A McKeon… - Annals of …, 2017 - Wiley Online Library
Objective To describe an expanded phenotypic spectrum and longitudinal outcome in 256
LGI1‐IgG–seropositive and/or CASPR2‐IgG–seropositive patients. Methods Patients were …

LGI1 antibody encephalitis: acute treatment comparisons and outcome

A Rodriguez, CJ Klein, E Sechi, E Alden… - Journal of Neurology …, 2022 - jnnp.bmj.com
Objective To compare acute treatment responses and long-term outcome in leucine-rich
glioma-inactivated 1 (LGI1) antibody encephalitis. Methods Retrospective case series of 118 …

Neurological autoantibody prevalence in epilepsy of unknown etiology

D Dubey, A Alqallaf, R Hays, M Freeman… - JAMA …, 2017 - jamanetwork.com
Importance Autoimmune epilepsy is an underrecognized condition, and its true incidence is
unknown. Identifying patients with an underlying autoimmune origin is critical because these …

Randomized placebo‐controlled trial of intravenous immunoglobulin in autoimmune LGI1/CASPR2 epilepsy

D Dubey, J Britton, A McKeon, A Gadoth… - Annals of …, 2020 - Wiley Online Library
Objective Drug‐resistant seizures are common in patients with leucine‐rich, glioma‐
inactivated 1 (LGI1)‐IgG associated and contactin‐associated protein‐like 2 (CASPR2)‐IgG …

Autoimmune GFAP astrocytopathy: prospective evaluation of 90 patients in 1 year

D Dubey, SR Hinson, EA Jolliffe, A Zekeridou… - Journal of …, 2018 - Elsevier
In this prospective evaluation of serum and CSF samples, all but two CSF GFAPα-IgG
positive patients had autoimmune meningoencephalomyelitis while serum GFAPα-IgG …

Movement disorders with neuronal antibodies: syndromic approach, genetic parallels and pathophysiology

B Balint, A Vincent, HM Meinck, SR Irani, KP Bhatia - Brain, 2018 - academic.oup.com
Movement disorders are a prominent and common feature in many autoantibody-associated
neurological diseases, a group of potentially treatable conditions that can mimic infectious …

Motor cortex and hippocampus are the two main cortical targets in LGI1-antibody encephalitis

V Navarro, A Kas, E Apartis, L Chami, V Rogemond… - Brain, 2016 - academic.oup.com
Encephalitis associated with antibodies against leucine-rich glioma-inactivated 1 (LGI1)
protein is increasingly recognized as an auto-immune disorder associated with …