Epigenetic clocks comprise a set of CpG sites whose DNA methylation levels measure
subject age. These clocks are acknowledged as a highly accurate molecular correlate of …

The precise temporal and spatial coordination of histone lysine methylation dynamics across
the epigenome regulates virtually all DNA-templated processes. A large number of histone …

Over the past 20 years, breakthrough discoveries of chromatin-modifying enzymes and
associated mechanisms that alter chromatin in response to physiological or pathological …

Histones are subject to a vast array of posttranslational modifications including acetylation,
methylation, phosphorylation, and ubiquitylation. The writers of these modifications play …

Methylation of cytosine in CpG dinucleotides and histone lysine and arginine residues is a
chromatin modification that critically contributes to the regulation of genome integrity …

DNA methylation is one of the best characterized epigenetic modifications. In mammals it is
involved in various biological processes including the silencing of transposable elements …

A major mechanism regulating the accessibility and function of eukaryotic genomes are the
covalent modifications to DNA and histone proteins that dependably package our genetic …

Chromatin modifying activities inherent to polycomb repressive complexes PRC1 and PRC2
play an essential role in gene regulation, cellular differentiation, and development. However …

Histone lysine methylation has emerged as a critical player in the regulation of gene
expression, cell cycle, genome stability, and nuclear architecture. Over the past decade, a …

Vertebrate CpG islands (CGIs) are short interspersed DNA sequences that deviate
significantly from the average genomic pattern by being GC-rich, CpG-rich, and …