Hippo pathway in cancer: aberrant regulation and therapeutic opportunities
PC Calses, JJ Crawford, JR Lill, A Dey - Trends in cancer, 2019 - cell.com
The Hippo pathway remains a central focus in both basic and translational research and is a
key modulator of developmental biology. Dysregulation of the pathway is associated with a …
key modulator of developmental biology. Dysregulation of the pathway is associated with a …
[HTML][HTML] YAP1 and its fusion proteins in cancer initiation, progression and therapeutic resistance
YAP1 is a transcriptional co-activator whose activity is controlled by the Hippo signaling
pathway. In addition to important functions in normal tissue homeostasis and regeneration …
pathway. In addition to important functions in normal tissue homeostasis and regeneration …
Photonic crystal enhanced fluorescence emission and blinking suppression for single quantum dot digital resolution biosensing
While nanoscale quantum emitters are effective tags for measuring biomolecular
interactions, their utilities for applications that demand single-unit observations are limited by …
interactions, their utilities for applications that demand single-unit observations are limited by …
MiR-375 reduces the stemness of gastric cancer cells through triggering ferroptosis
H Ni, H Qin, C Sun, Y Liu, G Ruan, Q Guo, T Xi… - Stem cell research & …, 2021 - Springer
Background Gastric cancer stem cells (CSCs) are the main causes of metastasis and drug
resistance. We previously indicated that miR-375 can inhibit Helicobacter pylori-induced …
resistance. We previously indicated that miR-375 can inhibit Helicobacter pylori-induced …
Hippo pathway dysregulation in gastric cancer: from Helicobacter pylori infection to tumor promotion and progression
The Hippo pathway plays a critical role for balancing proliferation and differentiation, thus
regulating tissue homeostasis. The pathway acts through a kinase cascade whose final …
regulating tissue homeostasis. The pathway acts through a kinase cascade whose final …
YAP/TAZ activation as a target for treating metastatic cancer
Yes-Associated Protein (YAP) and Transcriptional Co-activator with PDZ-binding Motif (TAZ)
have both emerged as important drivers of cancer progression and metastasis. YAP and …
have both emerged as important drivers of cancer progression and metastasis. YAP and …
The role of photoactivated and non-photoactivated verteporfin on tumor
C Wei, X Li - Frontiers in pharmacology, 2020 - frontiersin.org
Verteporfin (VP) has long been clinically used to treat age-related macular degeneration
(AMD) through photodynamic therapy (PDT). Recent studies have reported a significant anti …
(AMD) through photodynamic therapy (PDT). Recent studies have reported a significant anti …
[HTML][HTML] miR-150-5p suppresses tumor progression by targeting VEGFA in colorectal cancer
X Chen, X Xu, B Pan, K Zeng, M Xu, X Liu, B He… - Aging (albany …, 2018 - ncbi.nlm.nih.gov
Abstract MicroRNA-150-5p (miR-150-5p) has been implicated in tumor initiation and
progression in a variety of cancers. However, its roles in colorectal cancer (CRC) remain …
progression in a variety of cancers. However, its roles in colorectal cancer (CRC) remain …
Cancer‐associated fibroblasts potentiate colorectal cancer progression by crosstalk of the IGF2–IGF1R and Hippo–YAP1 signaling pathways
Colorectal cancer (CRC) is one of the most common cancers worldwide. The tumor
microenvironment exerts crucial effects in driving CRC progression. Cancer‐associated …
microenvironment exerts crucial effects in driving CRC progression. Cancer‐associated …
The E3 ubiquitin ligase, FBXW5, promotes the migration and invasion of gastric cancer through the dysregulation of the Hippo pathway
Y Yao, Z Liu, S Huang, C Huang, Y Cao, L Li… - Cell death …, 2022 - nature.com
F-box and WD repeat domain-containing 5 (FBXW5), with WD40 repeats, can bind to the
PPxY sequence of the large tumor suppressor kinases 1/2 (LATS1/2) kinase domain …
PPxY sequence of the large tumor suppressor kinases 1/2 (LATS1/2) kinase domain …