The glycine receptor chloride channel (GlyR) is a member of the nicotinic acetylcholine
receptor family of ligand-gated ion channels. Functional receptors of this family comprise five …

Although general anaesthesia has been of tremendous importance for the development of
surgery, the underlying mechanisms by which this state is achieved are only just beginning …

Lösel, Ralf M., Elisabeth Falkenstein, Martin Feuring, Armin Schultz, Hanns-Christian
Tillmann, Karin Rossol-Haseroth, and Martin Wehling. Nongenomic Steroid Action …

The molecular mechanisms of general anaesthetics have remained largely obscure since
their introduction into clinical practice just over 150 years ago. This review describes the …

Transmitter-gated ion channels mediate rapid synaptic transmission in the CNS and
constitute important targets for many neuroactive drugs. Inhibitory glycine receptors (GlyRs) …

The mechanisms of general anesthesia in the central nervous system are finally yielding to
molecular examination. As a result of research during the past several decades, a group of …

The hypnotic agent propofol has pharmacokinetic characteristics that allow for rapid onset
and offset of drug effect and fast elimination from the body. Elderly patients show a greater …

Neuroactive steroids are potent endogenous neuromodulators with rapid actions in the
central nervous system. Neuroactive steroids have been claimed to have specific …

Neuroactive steroids have some of their most potent actions by augmenting the function of
GABAA receptors. Endogenous steroid actions on GABAA receptors may underlie important …

Glycinergic neurotransmission has long been known for its role in spinal motor control.
During the last two decades, additional functions have become increasingly recognized …