Relative biological effectiveness (RBE) values for proton beam therapy. Variations as a function of biological endpoint, dose, and linear energy transfer

H Paganetti - Physics in Medicine & Biology, 2014 - iopscience.iop.org
Proton therapy treatments are based on a proton RBE (relative biological effectiveness)
relative to high-energy photons of 1.1. The use of this generic, spatially invariant RBE within …

Chondrosarcoma resistance to radiation therapy: Origins and potential therapeutic solutions

A Gilbert, M Tudor, J Montanari, K Commenchail… - Cancers, 2023 - mdpi.com
Simple Summary This review article aims in describing the origins of chondrosarcoma
radiation-resistance and proposes several potential solutions in order to improve the …

DNA strand break induction of aqueous plasmid DNA exposed to 30 MeV protons at ultra-high dose rate

D Ohsawa, Y Hiroyama, A Kobayashi… - Journal of radiation …, 2022 - academic.oup.com
Radiation cancer therapy with ultra-high dose rate exposure, so called FLASH radiotherapy,
appears to reduce normal tissue damage without compromising tumor response. The aim of …

Tumor oxygenation and cancer therapy—then and now

VS Hughes, JM Wiggins… - The British journal of …, 2018 - academic.oup.com
In 2012, cancer affected 14.1 million people worldwide and was responsible for 8.2 million
deaths. The disease predominantly affects aged populations and is one of the leading …

Models for translational proton radiobiology—from bench to bedside and back

T Suckert, S Nexhipi, A Dietrich, R Koch… - Cancers, 2021 - mdpi.com
Simple Summary An increasing number of cancer patients are treated with proton therapy.
Nevertheless, there are still open questions that require preclinical studies, for example …

Intermediate LET-like effect in distal part of proton Bragg peak revealed by track-ends imaging during super-Fricke radiolysis

J Audouin, P Hofverberg, Y Ngono-Ravache… - Scientific Reports, 2023 - nature.com
Upstream of the efficiency of proton or carbon ion beams in cancer therapy, and to optimize
hadrontherapy results, we analysed the chemistry of Fricke solutions in track-end of 64-MeV …

Difference in the relative biological effectiveness and DNA damage repair processes in response to proton beam therapy according to the positions of the spread out …

H Hojo, T Dohmae, K Hotta, R Kohno, A Motegi… - Radiation …, 2017 - Springer
Background Cellular responses to proton beam irradiation are not yet clearly understood,
especially differences in the relative biological effectiveness (RBE) of high-energy proton …

Spot scanning and passive scattering proton therapy: relative biological effectiveness and oxygen enhancement ratio in cultured cells

H Iwata, H Ogino, S Hashimoto, M Yamada… - International Journal of …, 2016 - Elsevier
Purpose To determine the relative biological effectiveness (RBE), oxygen enhancement
ratio (OER), and contribution of the indirect effect of spot scanning proton beams, passive …

Induction of DNA strand breaks and oxidative base damages in plasmid DNA by ultra-high dose rate proton irradiation

T Konishi, T Kusumoto, Y Hiroyama… - … Journal of Radiation …, 2023 - Taylor & Francis
Purpose Radiation cancer therapy with ultra-high dose rate (UHDR) exposure, so-called
FLASH radiotherapy, appears to reduce normal tissue damage without compromising tumor …

Hadrontherapy interactions in molecular and cellular biology

J Thariat, S Valable, C Laurent, S Haghdoost… - International journal of …, 2019 - mdpi.com
The resistance of cancer cells to radiotherapy is a major issue in the curative treatment of
cancer patients. This resistance can be intrinsic or acquired after irradiation and has various …