Regulation of small gtpases by gefs, gaps, and gdis
J Cherfils, M Zeghouf - Physiological reviews, 2013 - journals.physiology.org
Small GTPases use GDP/GTP alternation to actuate a variety of functional switches that are
pivotal for cell dynamics. The GTPase switch is turned on by GEFs, which stimulate …
pivotal for cell dynamics. The GTPase switch is turned on by GEFs, which stimulate …
Covalent inhibitors allosterically block the activation of rho family proteins and suppress cancer cell invasion
Z Sun, H Zhang, Y Zhang, L Liao, W Zhou… - Advanced …, 2020 - Wiley Online Library
Abstract The Rho family GTPases are crucial drivers of tumor growth and metastasis.
However, it is difficult to develop GTPases inhibitors due to a lack of well‐characterized …
However, it is difficult to develop GTPases inhibitors due to a lack of well‐characterized …
[HTML][HTML] Systemic analysis of the prognosis-related RNA alternative splicing signals in melanoma
D Xue, P Cheng, J Jiang, Y Ren, D Wu… - … medical journal of …, 2020 - ncbi.nlm.nih.gov
Background Alternative splicing (AS), the mechanism underlying the occurrence of protein
diversity, may result in cancer genesis and development when it becomes out of control, as …
diversity, may result in cancer genesis and development when it becomes out of control, as …
Modeling Epac1 interactions with the allosteric inhibitor AM-001 by co-solvent molecular dynamics
M Bufano, M Laudette, JP Blondeau… - Journal of Computer …, 2020 - Springer
The exchange proteins activated by cAMP (EPAC) are implicated in a large variety of
physiological processes and they are considered as promising targets for a wide range of …
physiological processes and they are considered as promising targets for a wide range of …
Mechanisms of activation of the guanine nucleotide exchange factor C3G
A Rodríguez Blázquez - 2023 - gredos.usal.es
[EN] C3G (also known as RapGEF1) is a ubiquitously expressed guanine nucleotide
exchange factor (GEF) that activates mainly the small GTPase Rap1 to promote integrin …
exchange factor (GEF) that activates mainly the small GTPase Rap1 to promote integrin …