Peroxisome proliferator-activated receptors (PPARs) and oxidative stress in physiological conditions and in cancer

G Muzio, G Barrera, S Pizzimenti - Antioxidants, 2021 - mdpi.com
Peroxisome proliferator-activated receptors (PPARs) belong to the nuclear hormone
receptor superfamily. Originally described as “orphan nuclear receptors”, they can bind both …

Lipid peroxidation: control of cell proliferation, cell differentiation and cell death

G Barrera, S Pizzimenti, MU Dianzani - Molecular aspects of medicine, 2008 - Elsevier
In recent years, it has become evident that lipid peroxidation is not only a mechanism for
deterioration of alimentary oils and fats, but can occur even in living cells, both in …

Over‐expression of different aldehyde dehydrogenase genes in Arabidopsis thaliana confers tolerance to abiotic stress and protects plants against lipid peroxidation …

SO Kotchoni, C Kuhns, A Ditzer… - Plant, cell & …, 2006 - Wiley Online Library
Aldehyde dehydrogenases (ALDHs) play a major role in the detoxification processes of
aldehydes generated in plants when exposed to abiotic stress. In previous studies, we have …

An overview of the effect of linoleic and conjugated‐linoleic acids on the growth of several human tumor cell lines

M Maggiora, M Bologna, MP Cerù… - … journal of cancer, 2004 - Wiley Online Library
Abstract Both n‐6 and n‐3 polyunsaturated fatty acids are dietary fats important for cell
function, being involved in several physiologic and pathologic processes, such as …

Mitochondrial dysfunction in cancer and neurodegenerative diseases: spotlight on fatty acid oxidation and lipoperoxidation products

G Barrera, F Gentile, S Pizzimenti, RA Canuto, M Daga… - Antioxidants, 2016 - mdpi.com
In several human diseases, such as cancer and neurodegenerative diseases, the levels of
reactive oxygen species (ROS), produced mainly by mitochondrial oxidative …

Differential gene expression profiles of gastric cancer cells established from primary tumour and malignant ascites

C Sakakura, A Hagiwara, M Nakanishi… - British journal of …, 2002 - nature.com
Advanced gastric cancer is often accompanied by metastasis to the peritoneum, resulting in
a high mortality rate. Mechanisms involved in gastric cancer metastasis have not been fully …

Protein carbonyl formation in response to propiconazole-induced oxidative stress

M Bruno, T Moore, S Nesnow, Y Ge - Journal of proteome …, 2009 - ACS Publications
Propiconazole, a widely used fungicide, is hepatotoxic and hepatotumorigenic in mice.
Previous genomic analysis of liver tissues from propiconazole-treated mice identified genes …

Hepatocyte nuclear factor-4 alpha mediates the stimulatory effect of peroxisome proliferator-activated receptor gamma co-activator-1 alpha (PGC-1 alpha) on glucose …

JN Boustead, BT Stadelmaier, AM Eeds… - Biochemical …, 2003 - ncbi.nlm.nih.gov
It has recently been shown that adenoviral-mediated expression of peroxisome proliferator-
activated receptor gamma co-activator-1 alpha (PGC-1 alpha) in hepatocytes stimulates …

Involvement of PPARs in cell proliferation and apoptosis in human colon cancer specimens and in normal and cancer cell lines

G Martinasso, M Oraldi, A Trombetta… - PPAR …, 2007 - Wiley Online Library
PPAR involvement in cell growth was investigated “in vivo” and “in vitro” and was correlated
with cell proliferation and apoptotic death.“In vivo” PPARγ and α were evaluated in colon …

Diabetes impairs the enzymatic disposal of 4-hydroxynonenal in rat liver

N Traverso, S Menini, P Odetti, MA Pronzato… - Free Radical Biology …, 2002 - Elsevier
This study assesses whether the HNE accumulation we formerly observed in liver
microsomes and mitochondria of BB/Wor diabetic rats depends on an increased rate of …