The relationships between hyaluronic acid (HA) and pathological microorganisms incite new
understandings on microbial infection, tissue penetration, disease progression and lastly …

Pharmacokinetic-pharmacodynamic (PKPD) modeling and simulation has evolved as an
important tool for rational drug development and drug use, where developed models …

OBJECTIVES: Beta-lactam antibiotics exhibit high interindividual variability in drug
concentrations in patients with critical illness which led to an interest in the use of …

Acinetobacter baumannii has emerged as an important nosocomial pathogen, particularly
for patients in intensive care units and with invasive indwelling devices. The most recent …

Animal infection models in the pharmacokinetic/pharmacodynamic (PK/PD) evaluation of
antimicrobial therapy serve an important role in preclinical assessments of new antibiotics …

Phage therapy has been viewed as a potential treatment for bacterial infections for over a
century. Yet, the year 2016 marks one of the first phase I/II human trials of a phage …

Beta-lactams (BL) are the first line agents for the antibiotic management of critically ill
patients with sepsis or septic shock. BL are hydrophilic antibiotics particularly subject to …

Intra-abdominal candidiasis (IAC) is one of the most common of invasive candidiasis
observed in critically ill patients. It is associated with high mortality, with up to 50% of deaths …

The purpose of this study was to develop a whole-body physiologically based
pharmacokinetic (WB-PBPK) model for ciprofloxacin for ICU patients, based on only plasma …

Acinetobacter baumannii is a common cause of health care associated infections worldwide.
A. pittii is an opportunistic pathogen also frequently isolated from Acinetobacter infections …