In the wake of the success of modern immunotherapy, oncolytic viruses (OVs) are currently
seen as a potential therapeutic option for patients with cancer who do not respond or fail to …

Selective destruction of neoplastic tissues by oncolytic viruses (OVs) leads to antigen-
agnostic boosting of neoantigen-specific cytotoxic T lymphocyte (CTL) responses, making …

Oncolytic viruses (OVs) encoding a variety of transgenes have been evaluated as
therapeutic tools to increase the efficacy of chimeric antigen receptor (CAR)–modified T cells …

Chimeric antigen receptor (CAR) T-cell therapy is an encouraging and fast-growing platform
used for the treatment of various types of tumors in human body. Despite the recent success …

Abstract In this White Paper, we discuss the current state of microbial cancer therapy. This
paper resulted from a meeting ('Microbial Based Cancer Therapy') at the US National …

Simple Summary Uveal melanoma is the most common primary intraocular malignancy in
adults. Although it can be controlled locally, half of the patients still develop metastases. To …

Oncolytic viruses (OVs) are emerging cancer therapeutics that offer a multifaceted
therapeutic platform for the benefits of replicating and lysing tumor cells, being engineered …

Cancer cells utilize multiple mechanisms to evade and suppress anticancer immune
responses creating a “cold” immunosuppressive tumor microenvironment. Oncolytic …

Oncolytic virus (OV) therapy is an anti-cancer approach that uses viruses that preferentially
infect, replicate in and kill cancer cells. Vesicular stomatitis virus (VSV, a rhabdovirus) is an …

Introduction Vesicular stomatitis virus (VSV) has long been a useful research tool in virology
and recently become an essential part of medicinal products. Vesiculovirus research is …