The MAP kinase signaling cascades: a system of hundreds of components regulates a diverse array of physiological functions

Y Keshet, R Seger - MAP Kinase Signaling Protocols: Second Edition, 2010 - Springer
Sequential activation of kinases within the mitogen-activated protein (MAP) kinase (MAPK)
cascades is a common, and evolutionary-conserved mechanism of signal transduction. Four …

The ERK cascade: a prototype of MAPK signaling

H Rubinfeld, R Seger - Molecular biotechnology, 2005 - Springer
Sequential activation of protein kinases within the mitogen-activated protein kinase (MAPK)
cascades is a common mechanism of signal transduction in many cellular processes. Four …

Inactivation of p42 MAP kinase by protein phosphatase 2A and a protein tyrosine phosphatase, but not CL100, in various cell lines

DR Alessi, N Gomez, G Moorhead, T Lewis, SM Keyse… - Current Biology, 1995 - cell.com
Background: Mitogen-activated protein (MAP) kinase is central to a signal transduction
pathway that triggers cell proliferation or differentiation. Activation of the p42 mapk isoform …

Heterodimerization and functional interaction between EGF receptor family members: a new signaling paradigm with implications for breast cancer research

HS Earp, TL Dawson, X Li, H Yu - Breast cancer research and treatment, 1995 - Springer
The EGF receptor (EGFR) and HER2 are members of a growth factor receptor family.
Overexpression of either protein in advanced breast cancer correlates with poor prognosis …

The regulation of amyloid precursor protein metabolism by cholinergic mechanisms and neurotrophin receptor signaling

S Roßner, U Ueberham, R Schliebs… - Progress in …, 1998 - Elsevier
The increased expression and/or abnormal processing of the amyloid precursor protein
(APP) is associated with the formation of amyloid plaques and cerebrovascular amyloid …

Growth hormone and prolactin stimulate tyrosine phosphorylation of insulin receptor substrate-1,-2, and-3, their association with p85 phosphatidylinositol 3-kinase …

T Yamauchi, Y Kaburagi, K Ueki, Y Tsuji… - Journal of Biological …, 1998 - ASBMB
Growth hormone (GH) and prolactin (PRL) binding to their receptors, which belong to the
cytokine receptor superfamily, activate Janus kinase (JAK) 2 tyrosine kinase, thereby …

Extracellular regulated kinases (ERK) 1 and ERK2 are authentic substrates for the dual-specificity protein-tyrosine phosphatase VHR: a novel role in down-regulating …

JL Todd, KG Tanner, JM Denu - Journal of Biological Chemistry, 1999 - ASBMB
The mammalian dual-specificity protein-tyrosine phosphatase VHR (forVH1-related) has
been identified as a novel regulator of extracellular regulated kinases (ERKs). To identify …

Confluence of vascular endothelial cells induces cell cycle exit by inhibiting p42/p44 mitogen-activated protein kinase activity

F Viñals, J Pouysségur - Molecular and cellular biology, 1999 - Taylor & Francis
Like other cellular models, endothelial cells in cultures stop growing when they reach
confluence, even in the presence of growth factors. In this work, we have studied the effect of …

Increased expression and subcellular translocation of the mitogen activated protein kinase kinase and mitogen-activated protein kinase in Alzheimer's disease

T Arendt, M Holzer, A Grossmann, D Zedlick, MK Bru - Neuroscience, 1995 - Elsevier
The sequential activation of the mitogen-activated protein kinase kinase and its substrate,
the mitogen-activated protein kinase is involved in a cascade of protein kinases which link a …

Growth Hormone-promoted Tyrosyl Phosphorylation of SHC Proteins and SHC Association with Grb2 (∗)

J VanderKuur, G Allevato, N Billestrup… - Journal of Biological …, 1995 - ASBMB
Growth hormone (GH) has been shown to stimulate the mitogen-activated protein (MAP)
kinases designated ERKs (extracellular signal regulated kinases) 1 and 2. One pathway by …