Genetic alterations drive tumor onset and progression. However, the cross-talk between
tumor cells and the benign components of the surrounding stroma can also promote the …

Major progress in the understanding and treatment of cancer have tremendously improved
our knowledge of this complex disease and improved the length and quality of patients' …

Abstract Space three dimension (3D) bioprinting provides a precise and bionic tumor model
for evaluating the compound effect of the space environment on tumors, thereby providing …

Neurodegenerative diseases and neurodevelopmental disorders have become increasingly
prevalent; however, the development of new pharmaceuticals to treat these diseases has …

The extracellular matrix interacts with cancer cells and is a key factor in the development of
cancer. Traditional two-dimensional models cannot mimic the natural in situ environment of …

Organs-on-chips (OoCs) are miniature microfluidic systems that have arguably become a
class of advanced in vitro models. Deep learning, as an emerging topic in machine learning …

Ovarian cancer (OC) is the fifth most frequent cause of cancer-related death in women.
Chemotherapy agent trabectedin, affecting cancer cells and tumor microenvironment, has …

The hypoxia associated with the transforming growth factor-β2 (TGF-β2)-induced epithelial
mesenchymal transition (EMT) of human retinal pigment epithelium (HRPE) cells is well …

Three-dimensional cell culture technology (3DCC) sits between two-dimensional cell culture
(2DCC) and animal models and is widely used in oncology research. Compared to 2DCC …

Purpose Radiotherapy is one of the essential treatment modalities for nasopharyngeal
carcinoma (NPC), however, radioresistance still poses challenges. Three-dimensional (3D) …